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Merck

A5605

Sigma-Aldrich

苯磺酸氨氯地平

≥98% (HPLC)

别名:

2-[(2-氨基乙氧基)-甲基]-4-(2-氯苯基)-1,4-二氢-6-甲基-3,5-吡啶二甲酸 3-乙基 5-甲酯苯磺酸酯, 活络喜(抗高血压药)

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About This Item

经验公式(希尔记法):
C20H25ClN2O5 · C6H5SO3H
分子量:
567.05
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

white

溶解度

DMSO: ≥20 mg/mL

SMILES 字串

OS(=O)(=O)c1ccccc1.CCOC(=O)C2=C(COCCN)NC(C)=C(C2c3ccccc3Cl)C(=O)OC

InChI

1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9)

InChI 密鑰

ZPBWCRDSRKPIDG-UHFFFAOYSA-N

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應用

苯磺酸氨氯地平是一种 L 型钙通道阻滞剂,可用于治疗心绞痛和高血压。氨氯地平还可抑制人表皮样癌细胞 A431 的生长,并对雄性大鼠具有抗生殖作用。

生化/生理作用

氨氯地平是一种 L 型钙通道阻滞剂。氨氯地平属于一类心血管药物,作用于 Ca V 1 或 L 型的电压门控钙通道。氨氯地平还具有降压和抗心绞痛作用。其活性主要存在于 (-)-异构体中。氨氯地平抑制人表皮样癌细胞 A431 的生长,对雄性大鼠有抗生殖作用。

特點和優勢

该化合物在受体分类和信号转导手册的钙通道页面上有重点介绍。如需浏览其他手册页面,请点击此处

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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Iron chelation therapy in patients with thalassemia major may not prevent iron overload in all organs, especially those in which iron enters cells through specific calcium channels. We designed a controlled pilot study to assess the potential of the calcium
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The purpose of this study was to evaluate a fixed olmesartan/amlodipine combination on blood pressure control, lipid profile, insulin sensitivity, and some inflammatory markers compared with single-drug monotherapy. A total of 276 hypertensive patients were randomly assigned to olmesartan 20

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Chromatograms

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