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About This Item
经验公式（希尔记法）:
C24H26BrN3O3
CAS号:
分子量:
484.39
EC號碼:
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24
推荐产品
等級
analytical standard
品質等級
化驗
≥97% (TLC)
技術
HPLC: suitable
gas chromatography (GC): suitable
應用
forensics and toxicology
pharmaceutical (small molecule)
veterinary
形式
neat
儲存溫度
2-8°C
SMILES 字串
[H][C@@]12Cc3cn(C)c4cccc(c34)[C@]1(C[C@@H](COC(=O)c5cncc(Br)c5)CN2C)OC
InChI
1S/C24H26BrN3O3/c1-27-13-17-8-21-24(30-3,19-5-4-6-20(27)22(17)19)9-15(12-28(21)2)14-31-23(29)16-7-18(25)11-26-10-16/h4-7,10-11,13,15,21H,8-9,12,14H2,1-3H3/t15-,21-,24+/m1/s1
InChI 密鑰
YSEXMKHXIOCEJA-FVFQAYNVSA-N
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一般說明
Nicergoline is an ergot derivative, which may be used in the treatment of affective, cognitive and behavioral disorders seen in older people. It is an α -adrenergic antagonist that may be used for companion animals like cats and dogs to treat, behavioral disorders, problems with aging, excessive vocaliztion and restessness.
應用
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
生化／生理作用
大脑和周边血管舒张剂
Nicergoline for dementia and other age associated forms of cognitive impairment
MF and LF
Cochrane database of systematic reviews (Online), 2001-2001 null
Maddison.EJ, et al.
Small Animal Clinical Pharmacology (2008)
Mohamed I Walash et al.
Journal of AOAC International, 91(2), 349-359 (2008-05-15)
A rapid, simple, and highly sensitive second-derivative synchronous fluorometric method has been developed for the simultaneous analysis of binary mixtures of cinnarizine (CN) and nicergoline (NIC). The method is based upon measurement of the native fluorescence of these drugs at
Antonio Moschetta et al.
Journal of lipid research, 46(10), 2221-2232 (2005-08-03)
Biliary lipids (bile salts, phospholipids, cholesterol, plant sterols) were determined in 89 vertebrate species (cartilaginous and bony fish, reptiles, birds, and mammals), and individual phospholipid classes were measured in 35 species. All samples contained conjugated bile salts (C(27) bile alcohol
Filippo Caraci et al.
Brain research, 1047(1), 30-37 (2005-05-11)
Nicergoline, a drug used for the treatment of Alzheimer's disease and other types of dementia, was tested for its ability to protect neurons against beta-amyloid toxicity. Pure cultures of rat cortical neurons were challenged with a toxic fragment of beta-amyloid
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