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KITALYSIS-CN

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KitAlysis ™ 高通量 Buchwald-Hartwig 胺化反应筛选试剂盒

别名:

Buchwald-Hartwig 胺化, 胺化筛查试剂盒

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About This Item

分類程式碼代碼:
12161503
NACRES:
NA.22

反應適用性

reaction type: Buchwald-Hartwig Amination
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Cross Couplings
reagent type: catalyst
core: palladium

儲存溫度

room temp

相关类别

一般說明

KitAlysis™高通量Buchwald–Hartwig氨化反应筛选试剂盒可帮助化学家快速而有效地筛选Buchwald–Hartwig C–N交叉耦合反应条件。快速确定最佳条件，使合成反应能够更快地扩展。所有必需化学品均已预先称重，易于使用。可下载逐步用户指南和实验电子表格，加快进程。

應用

根据用户’的底物，可以运行四种可能的筛选。以下超链接为用户提供了分步操作指南和可下载的为每次筛选设计的实验excel表格。

两种溶剂，弱碱（Cs2CO3）
在此处下载实验excel文件
两种溶剂，强碱（NaOt-Bu）
在此处下载实验excel文件
一种溶剂（二恶烷），两种碱
在此处下载实验excel文件
一种溶剂（DMAc），两种碱
在此处下载实验excel文件

每个试剂盒中包含4组筛选，包括以下内容：
每个可定制的筛选套件包含



  • 12 X 2每个预称重的催化剂 (1 μmol) 在带有磁性搅拌棒的单个小瓶中
  • 2种碱(NaOt-Bu and Cs2CO3)
  • 2个装在安瓿瓶中的脱气无水溶剂（二氧六环和DMAc）
  • 2 个带有搅拌棒的底物反应瓶
  • 1 个内标
  • 4个反应遮挡可替换膜
用TLC-MS 监测反应进程，通过以下 方案

使用KitAlysis效果最佳 B台式插入盒 和 24-孔反应块 （单独销售）。

特點和優勢

  • 由合成化学家设计和测试
  • 轻松平行运行 24 个微型反应
  • 含 1 μmol 催化剂、3 当量碱、0.1 M 浓度的 10μmol 反应
  • 可定制的 Excel 模板，可快速计算，并易于整合到电子实验室笔记本中

法律資訊

KitAlysis is a trademark of Sigma-Aldrich Co. LLC

仅试剂盒组分

产品编号
说明
  • SnapIT Ampule Opener, Regular, for 1-2ml, 5-10ml, 10-15ml ampoules 1 EA

试剂盒组分也可单独购买

产品编号
说明
化学品安全说明书
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价格

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訊號詞

Danger

危險分類

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Eye Dam. 1 - Repr. 1B - Self-heat. 1 - Skin Corr. 1B - STOT RE 2 Oral - STOT SE 3

標靶器官

Central nervous system, Kidney,Adrenal gland,Testes, Respiratory system

安全危害

EUH019

儲存類別代碼

4.2 - Pyrophoric and self-heating hazardous materials

閃點（°F）

-4.0 °F - closed cup

閃點（°C）

-20 °C - closed cup

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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High-Throughput Experimentation in Catalysis and Materials Science.
Gordillo A, et al. et al.
Ullmann's Encyclopedia of Industrial Chemistry (2014)
Scientist-Led High-Throughput Experimentation (HTE) and Its Utility in Academia and Industry.
Schmink JR, et al.
Aldrichimica Acta, 46, 71-80 (2013)
Spencer D Dreher et al.
Journal of the American Chemical Society, 130(29), 9257-9259 (2008-06-28)
Microscale parallel experimentation was used to discover three catalyst systems capable of coupling secondary organotrifluoroborates with sterically and electronically demanding aryl chlorides and bromides. The ensuing results represent the first comprehensive study of alkylboron coupling to aryl chlorides and, in
Karl D Collins et al.
Nature chemistry, 6(10), 859-871 (2014-09-23)
New organic reactivity has often been discovered by happenstance. Several recent research efforts have attempted to leverage this to discover new reactions. In this Review, we attempt to unify reported approaches to reaction discovery on the basis of the practical

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实验方案

Two solvents (Dioxane, DMAc), weak base (Cs2CO3) Step-by-Step Guide for Buchwald-Hartwig Amination Screening Kit

Solutions & slurries to make: Go to the online user set-up page to enter molecular weights into the downloadable excel file.

Catalyst Screening followed by TLC-MS for Reaction Progress Analysis using KitAlysis™

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