I2002
Isocitric Dehydrogenase (NADP) from porcine heart
Type IV, buffered aqueous glycerol solution, 3-20 units/mg protein
Sinonimo/i:
threo-Ds-Isocitrate: NADP+ oxidoreductase, ICDH, IDH
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About This Item
Prodotti consigliati
Tipo
Type IV
Livello qualitativo
Stato
buffered aqueous glycerol solution
Qualità
≤ 0.2% of main activity is obtained with NAD as cofactor.
Attività specifica
3-20 units/mg protein
Composizione
Protein biuret
Condizioni di spedizione
wet ice
Temperatura di conservazione
2-8°C
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Categorie correlate
Applicazioni
Isocitric dehydrogenase (IDH) has been used:
- for in vitro activity assay to study the effects of thorium on citric acid cycle enzymes in the mitochondrial respiration pathway
- as a standard to measure the impact of temperature on nicotinamide diphosphate (NADP)-IDH activity
- in isocitrate assay
Azioni biochim/fisiol
Isocitrate dehydrogenase (IDH) is a homodimeric enzyme and participates in several processes such as adapting to hypoxia, histone demethylation, and DNA modification. This enzyme has three isoforms like IDH1, IDH2, and IDH3.
Definizione di unità
One unit will convert 1.0 μmole of isocitrate to α-ketoglutarate per min at pH 7.4 at 37 °C.
Stato fisico
Solution in 50% glycerol in EDTA buffer salts, pH 6.0
Inibitore
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Dispositivi di protezione individuale
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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