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P0300000

Acetaminofene

European Pharmacopoeia (EP) Reference Standard

Sinonimo/i:

4′-idrossiacetanilide, 4-acetamidofenolo, N-(4-idrossifenil)acetammide, N-acetil-4-amminofenolo, APAP, Paracetamolo

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About This Item

Formula condensata:
CH3CONHC6H4OH
Numero CAS:
103-90-2
Peso molecolare:
151.16
Beilstein:
2208089
Numero CE:
203-157-5
Numero MDL:
MFCD00002328
Codice UNSPSC:
41116107
ID PubChem:
329820028
NACRES:
NA.24

Grado

pharmaceutical primary standard

Descrizione

API family: acetaminophen

Famiglia di API

paracetamol, acetaminophen

Produttore/marchio commerciale

EDQM

tecniche

HPLC: suitable
gas chromatography (GC): suitable

Punto di fusione

168-172 °C (lit.)

applicazioni

pharmaceutical (small molecule)

Formato

neat

Stringa SMILE

CC(=O)Nc1ccc(O)cc1

InChI

1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)
RZVAJINKPMORJF-UHFFFAOYSA-N

Informazioni sul gene

human ... FAAH(2166) , PTGS1(5742) , PTGS2(5743) , TRPV1(7442)

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Descrizione generale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Applicazioni

Paracetamol EP reference standard, intended for use only as specifically prescribed in the European Pharmacopoeia.
Analgesico.

Confezionamento

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Altre note

Sales restrictions may apply.

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N° Catalogo
Descrizione
Determinazione del prezzo

PHR1005

Acetaminofene, Pharmaceutical Secondary Standard; Certified Reference Material

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4-Aminophenol (Acetaminophen Related Compound K) (Paracetamol Impurity K), Pharmaceutical Secondary Standard; Certified Reference Material

PHR1149

4′-cloroacetanilide, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1150

Acetaminophen Related Compound F, Pharmaceutical Secondary Standard; Certified Reference Material

1003009

Acetaminofene, United States Pharmacopeia (USP) Reference Standard

1021204

4-Aminophenol, United States Pharmacopeia (USP) Reference Standard

PHR1225

3-Aminophenol, Pharmaceutical Secondary Standard; Certified Reference Material

1003010

Acetaminophen Related Compound A, United States Pharmacopeia (USP) Reference Standard

PHR1531

2-acetamidofenolo, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1530

Acetaminophen Related Compound D, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1612

Acetaminophen Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

1003027

Composto B correlato ad acetaminofene, United States Pharmacopeia (USP) Reference Standard

1003042

Acetaminophen Related Compound D, United States Pharmacopeia (USP) Reference Standard

1003100

Composto J correlato ad acetaminofene, United States Pharmacopeia (USP) Reference Standard

1003031

Composto C correlato ad acetaminofene, United States Pharmacopeia (USP) Reference Standard

PHR1642

N-(4-idrossifenil)propanamide, Pharmaceutical Secondary Standard; Certified Reference Material

1003064

Acetaminophen Related Compound F, United States Pharmacopeia (USP) Reference Standard

1026004

m-Aminophenol, United States Pharmacopeia (USP) Reference Standard

Y0001781

Acetaminofene, European Pharmacopoeia (EP) Reference Standard

PHR1745

4-Aminophenol hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

BP371

Acetaminofene, British Pharmacopoeia (BP) Reference Standard

Y0001945

4′-cloroacetanilide, European Pharmacopoeia (EP) Reference Standard

Y0001955

Paracetamol impurity K, European Pharmacopoeia (EP) Reference Standard

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

364.3 °F - Pensky-Martens closed cup

Punto d’infiammabilità (°C)

184.6 °C - Pensky-Martens closed cup

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Certificati d'analisi (COA)

Lot/Batch Number

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Ibuprofene European Pharmacopoeia (EP) Reference Standard

I0020000

Ibuprofene

4-Aminophenol ≥98%

Sigma-Aldrich

A71328

4-Aminophenol

Ibuprofene ≥98% (GC)

Sigma-Aldrich

I4883

Ibuprofene

4-Aminophenol (Acetaminophen Related Compound K) (Paracetamol Impurity K) Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1148

4-Aminophenol (Acetaminophen Related Compound K) (Paracetamol Impurity K)

Acetylsalicylic acid ≥99.0%

Sigma-Aldrich

A5376

Acetylsalicylic acid

USP

USP

1003010

Acetaminophen Related Compound A

Acetaminophen solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

A-064

Acetaminophen solution

Propacetamol hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML1777

Propacetamol hydrochloride

S M de Morais et al.
Gastroenterology, 102(2), 577-586 (1992-02-01)
Gilbert's syndrome occurs in 5%-7% of the human population and is caused by an inherited deficiency in the glucuronidation of endogenous bilirubin, resulting in its accumulation and jaundice. The authors of the present study have previously shown that rats with
Edward Munsterhjelm et al.
Anesthesiology, 103(4), 712-717 (2005-09-30)
Acetaminophen (paracetamol) is widely used for postoperative analgesia. Its mechanism of action is inhibition of prostaglandin synthesis in the central nervous system, and acetaminophen is traditionally not considered to influence platelet function. The authors studied the dose-dependent inhibition of platelet
Mitchell R McGill et al.
Pharmaceutical research, 30(9), 2174-2187 (2013-03-07)
Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic doses, overdose causes mitochondrial dysfunction and centrilobular necrosis in the liver. The first studies of APAP metabolism and activation were published more than 40 years ago.
Garry G Graham et al.
Drug safety, 28(3), 227-240 (2005-03-01)
The excellent tolerability of therapeutic doses of paracetamol (acetaminophen) is a major factor in the very wide use of the drug. The major problem in the use of paracetamol is its hepatotoxicity after an overdose. Hepatotoxicity has also been reported
Garry G Graham et al.
Inflammopharmacology, 21(3), 201-232 (2013-05-31)
Paracetamol is used worldwide for its analgesic and antipyretic actions. It has a spectrum of action similar to that of NSAIDs and resembles particularly the COX-2 selective inhibitors. Paracetamol is, on average, a weaker analgesic than NSAIDs or COX-2 selective
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