A5376

Acetylsalicylic acid

≥99.0%

• Sinonimo/i: 2-Acetoxybenzoic acid, O-Acetylsalicylic acid, ASA, Aspirin
• Formula condensata: 2-(CH₃CO₂)C₆H₄CO₂H
• Numero CAS: 50-78-2
• Peso molecolare: 180.16
• Beilstein: 779271
• Numero CE: 200-064-1
• Numero MDL: MFCD00002430
• Codice UNSPSC: 12352106
• ID PubChem: 24278218
• NACRES: NA.21

Proprietà

• Origine biologica: synthetic
• Livello qualitativo: 200
• Saggio: ≥99.0%
• Forma fisica: powder
• Colore: white
• pKa (25 °C): 3.5
• Punto di fusione: 134-136 °C (lit.)
• Solubilità: H₂O: 10 mg/mL at 37 °C(lit.); H₂O: 3 mg/mL at 25 °C(lit.); ethanol: 50 mg/mL; aqueous base: decomposes
• ε (coefficiente d’estinzione): 190 at 298 nm in aqueous base at 1 mM; 409 at 231 nm in aqueous base at 1 mM; 466 at 230 nm in aqueous acid at 1 mM; 68 at 278 nm in aqueous acid at 1 mM
• Stringa SMILE: CC(=O)Oc1ccccc1C(O)=O
• InChI: 1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12); BSYNRYMUTXBXSQ-UHFFFAOYSA-N
• Informazioni sul gene: human ... ITGA2B(3674) , ITGB3(3690) , PTGS1(5742) , PTGS2(5743)

Descrizione

Descrizione generale

Acetylsalicylic acid is an organic compound commonly referred to as aspirin. It works by blocking the production of compounds in the body that cause pain, swelling, and fever. Acetylsalicylic acid also serves a vital function in preventing blood clots from forming in the arteries. In research, acetylsalicylic acid is studied for its role in oxidative stress, and in cancer research as a biomarker.

Azioni biochim/fisiol

Blocks the production of prostaglandins by inhibiting cyclooxygenase (prostaglandin H synthase), with greater selectivity toward the COX-1 isoform. The antithrombotic effect is due to the inhibition of COX-1 in platelets that blocks thromboxane production and platelet aggregation. Chemopreventive against colorectal and other solid tumors.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302
• Consigli di prudenza: P264 - P270 - P301 + P312 - P501
• Classi di pericolo: Acute Tox. 4 Oral
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): 482.0 °F
• Punto d’infiammabilità (°C): 250 °C
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Faceshields, Gloves