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Sigma-Aldrich

α-Cyano-4-hydroxycinnamic acid

matrix substance for MALDI-MS, Ultra pure

Sinonimo/i:

α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA

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About This Item

Formula condensata:
HOC6H4CH=C(CN)CO2H
Numero CAS:
28166-41-8
Peso molecolare:
189.17
Beilstein:
3271427
Numero CE:
248-879-1
Numero MDL:
MFCD00004204
Codice UNSPSC:
41116105
ID PubChem:
329755873
NACRES:
NA.21

Grado

matrix substance for MALDI-MS

Livello qualitativo

100

Forma fisica

solid

Classi chimiche degli analiti

glycans, peptides, proteins

tecniche

MALDI-MS: suitable

Punto di fusione

245-250 °C (lit.)
245-250 °C

Solubilità

methanol: 10 mg/mL, clear

Cationi in tracce

Al: ≤1 mg/kg
Ba: ≤1 mg/kg
Ca: ≤1 mg/kg
Cd: ≤1 mg/kg
Co: ≤1 mg/kg
Cr: ≤1 mg/kg
Cu: ≤1 mg/kg
Fe: ≤1 mg/kg
K: ≤1 mg/kg
Li: ≤1 mg/kg
Mg: ≤1 mg/kg
Mn: ≤1 mg/kg
Na: ≤1 mg/kg
Ni: ≤1 mg/kg
Pb: ≤1 mg/kg
Sr: ≤1 mg/kg
Zn: ≤1 mg/kg

Temperatura di conservazione

2-8°C

Stringa SMILE

OC(=O)\C(=C\c1ccc(O)cc1)C#N

InChI

1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+
AFVLVVWMAFSXCK-VMPITWQZSA-N

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Descrizione generale

α-Cyano-4-hydroxycinnamic acid (α-CHCA) functions as matrix and helps in facilitating ionization of proteins and peptides in a matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometer.

Applicazioni

It was used as matrix in improving the detection of low concentration protein digests on MALDI-TOF.

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Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H317

Classi di pericolo

Skin Sens. 1B

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificati d'analisi (COA)

Lot/Batch Number
BCCF7066
BCCD4901
BCCB6242
BCCB4528
BCCB0620

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Journal of biomolecular techniques : JBT, 14(4), 298-307 (2004-01-13)
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D(4)-α-Cyano-4-hydroxycinnamic acid (D(4)-CHCA) has been synthesized for use as a matrix for matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS) and MALDI-MS imaging (MSI) of small molecule drugs and endogenous compounds. MALDI-MS analysis of small molecules has historically been hindered by interference
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