900913

Tetrazine-PEG5-NHS ester

≥95%

• Sinonimo/i: Tz-PEG5-NHS
• Formula empirica (notazione di Hill): C₂₇H₃₆N₆O₁₀
• Numero CAS: 1682653-80-0
• Peso molecolare: 604.61
• Numero MDL: MFCD28505547
• Codice UNSPSC: 12352108
• NACRES: NA.22

Proprietà

• Livello qualitativo: 100
• Saggio: ≥95%
• Stato: powder or crystals
• Impiego in reazioni chimiche: reaction type: click chemistry; reagent type: linker
• Gruppo funzionale: NHS ester
• Temperatura di conservazione: −20°C
• Stringa SMILE: O=C(NCC1=CC=C(C2=NN=CN=N2)C=C1)CCOCCOCCOCCOCCOCCC(ON3C(CCC3=O)=O)=O
• InChI: 1S/C27H36N6O10/c34-23(28-19-21-1-3-22(4-2-21)27-31-29-20-30-32-27)7-9-38-11-13-40-15-17-42-18-16-41-14-12-39-10-8-26(37)43-33-24(35)5-6-25(33)36/h1-4,20H,5-19H2,(H,28,34); DUPHIQYIPUTDJS-UHFFFAOYSA-N

Descrizione

Descrizione generale

Tetrazine-PEG5-NHS ester has an N-hydroxysuccinimide (NHS) ester that can be reacted with primary amines and tetrazine, which is reactive to trans-cyclooctenes. Hydrogen substituted tetrazines demonstrate exceptionally fast kinetics, generally at least 10-fold faster compared to methyl substituted tetrazines. The aqueous solubility of this reagent is substantially enhanced by a hydrophilic polyethylene glycol (PEG) spacer arm.

Applicazioni

Tetrazine-PEG5-NHS ester (Tz-PEG₅-NHS) can be used in click chemistry applications such as the preparation of chitosan-polyacrylamide microspheres utilizing selective tetrazine-trans-cyclooctene (Tz-TCO) ligation and the construction of copper-64 radiolabeled antibody by the click reaction.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable