761524

Dibenzocyclooctyne-N-hydroxysuccinimidyl ester

for Copper-free Click Chemistry

• Sinonimo/i: DBCO-NHS ester, DBCO-SE
• Formula empirica (notazione di Hill): C₂₃H₁₈N₂O₅
• Peso molecolare: 402.40
• Numero MDL: MFCD24386367
• Codice UNSPSC: 12352108
• ID PubChem: 329766555
• NACRES: NA.22

Proprietà

• Livello qualitativo: 100
• Stato: solid
• Impiego in reazioni chimiche: reaction type: click chemistry; reagent type: cross-linking reagent
• Punto di fusione: 149-157 (decomposition)
• Gruppo funzionale: NHS ester
• Temperatura di conservazione: −20°C
• Stringa SMILE: O=C(CCC(ON(C(CC1)=O)C1=O)=O)N2CC3=C(C=CC=C3)C#CC4=C2C=CC=C4
• InChI: 1S/C23H18N2O5/c26-20(13-14-23(29)30-25-21(27)11-12-22(25)28)24-15-18-7-2-1-5-16(18)9-10-17-6-3-4-8-19(17)24/h1-8H,11-15H2; XCEBOJWFQSQZKR-UHFFFAOYSA-N

Descrizione

Descrizione generale

DBCO-NHS ester is commonly used in bioconjugation. It consists of an NHS ester that reacts with primary amines on biomolecules and an alkyne group that allows for a specific reaction with molecules containing azides. This reaction is carried out through a copper-free click chemistry process called strain-promoted alkyne-azide cycloaddition.

Applicazioni

Dibenzocyclooctyne-N-hydroxysuccinimidyl ester is commonly used:

• In the modification and labeling of biomolecules such as antibodies and streptavidin by introducing DBCO groups onto their surfaces
• As a cross linker to conjugate peptide antigens onto the surface of poly(lactic-co-glycolic acid) (PLGA) nanoparticles

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable