411361

Diethyl (bromodifluoromethyl)phosphonate

96%

• Sinonimo/i: (Bromodifluoromethyl)phosphonic acid diethyl ester
• Formula condensata: BrCF₂P(O)(OC₂H₅)₂
• Numero CAS: 65094-22-6
• Peso molecolare: 267.01
• Numero MDL: MFCD00069118
• Codice UNSPSC: 12352108
• ID PubChem: 24865745
• NACRES: NA.22

Proprietà

• Livello qualitativo: 100
• Saggio: 96%
• Stato: liquid
• Impiego in reazioni chimiche: reaction type: C-C Bond Formation
• Indice di rifrazione: n20/D 1.417 (lit.)
• P. ebollizione: 40-41 °C/0.05 mmHg (lit.)
• Densità: 1.503 g/mL at 25 °C (lit.)
• Gruppo funzionale: bromo; fluoro; phosphonate
• Stringa SMILE: CCOP(=O)(OCC)C(F)(F)Br
• InChI: 1S/C5H10BrF2O3P/c1-3-10-12(9,11-4-2)5(6,7)8/h3-4H2,1-2H3; QRADKVYIJIAENZ-UHFFFAOYSA-N

Descrizione

Applicazioni

Reactant for:

• Preparation of phosphopeptide mimetic prodrugs targeted to Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 (Stat3)
• Synthesis of Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory difluoromethylphosphonic acid derivatives via multi step synthesis with Suzuki coupling and resolution as key steps
• P-C bond cleavage on basic hydrolysis
• Preparation of a prodrug for intracellular delivery of protein tyrosine phosphatase 1B (PTP1B) inhibitor (nonhydrolyzable difluoromethylphosphonate moiety)

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves