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390690

Sigma-Aldrich

(2-Hydroxypropyl)-α-cyclodextrin

average Mw ~1,180

Sinonimo/i:

α‐HPCD, 2OHpαCD, 2‐hydroxypropyl‐α‐CD, HPαCD, HP-α-CD

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About This Item

Numero CAS:
128446-33-3
Numero MDL:
MFCD00197866
Codice UNSPSC:
12352201
NACRES:
NA.22

Stato

powder

Livello qualitativo

100

Attività ottica

[α]20/D +125°, c = 1 in H2O

PM

average Mw ~1,180

Grado di funzionalizzazione

0.6 molar substitution

Punto di fusione

245 °C (dec.) (lit.)

Stringa SMILE

O1[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@@H]([C@@H](O[C@H]4O[C@@H]([C@@H](O[C@H]5O[C@@H]([C@@H](O[C@H]6O[C@@H]([C@@H](O[C@H]7O[C@@H]([C@@H]1[C@H]([C@@H]7O)O)COCC(O)C)[C@H]([C@@H]6O)O)COCC(O)C)[C@H]([C@@H]5O)O)COCC(O)C)[C@H]([C@@H]4O)O)COCC(O)C)[C@H]([C@@H]3O)O)C

InChI

1S/C54H96O36/c1-19(55)7-73-13-25-43-31(61)37(67)49(79-25)86-44-26(14-74-8-20(2)56)81-51(39(69)33(44)63)88-46-28(16-76-10-22(4)58)83-53(41(71)35(46)65)90-48-30(18-78-12-24(6)60)84-54(42(72)36(48)66)89-47-29(17-77-11-23(5)59)82-52(40(70)34(47)64)87-45-27(15
PMPYGZCSMCXHTA-WABPNHHRSA-N

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Descrizione generale

(2-Hydroxypropyl)-α-cyclodextrin is a hydroxyalkyl derivative of cyclodextrin, which is generally used as a substitute of α-cyclodextrin for potential application in food, cosmetics and pharmaceutical industries. It may be used as a parenteral drug carrier on account of its attractive characteristics such as: a greater extent of solubility in water, high dissolution capacity for weakly soluble analytes, and low toxicity.

Applicazioni

  • (2-Hydroxypropyl)-α-cyclodextrin can be used as a chiral selector to resolve tryptophan racemate by capillary electrophoresis.
  • It can be used to synthesize biodegradable polyrotaxanes for fabricating blood-contacting devices.
  • Co-polymer based on (2-hydroxypropyl)-α-cyclodextrin cross-linked with polyethylenimine can be used as a gene delivery vector.
  • It can also be used as stabilizer for antibacterial iodine formulations, as it forms a stable inclusion complex with iodine and improves aqueous solubility.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
STBK8576
STBK6088
STBK3937
STBK2754
STBJ7674

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Interaction of iodine with 2-hydroxypropyl-α-cyclodextrin and its bactericidal activity.
Tomono K, et al.
Drug Development and Industrial Pharmacy, 28(10), 1303-1309 (2002)
2-Hydroxypropylated cyclodextrins as a sustained-release carrier for fragrance materials
TANAKA M, et al.
Chemical & Pharmaceutical Bulletin, 44(2), 416-420 (1996)
Recognition mechanism of d-and l-tryptophan enantiomers using 2-hydroxypropyl-α-or β-cyclodextrins as chiral selectors.
Malta LFB, et al.
Tetrahedron Asymmetry, 19(10), 1182-1188 (2008)
A novel co-polymer based on hydroxypropyl α-cyclodextrin conjugated to low molecular weight polyethylenimine as an in vitro gene delivery vector.
Huang H, et al.
International Journal of Molecular Sciences, 9(11), 2278-2289 (2008)
Effect of biodegradable polyrotaxanes on platelet activation.
Yui N, et al.
Bioconjugate Chemistry, 9(1), 118-125 (1998)
Visualizza tutti i documenti correlati

Global Trade Item Number

SKUGTIN
390690-5G4061833424759
390690-25G4061833482551

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