Pular para o conteúdo
Merck

High-performance liquid chromatographic enantioseparation of bicalutamide and its related compounds.

Journal of chromatography. A (2005-11-30)
Roland Török, Adám Bor, György Orosz, Ferenc Lukács, Daniel W Armstrong, Antal Péter
RESUMO

Direct high-performance liquid chromatographic methods were developed for the enantioseparation of (R,S)-bicalutamide (1) and its analogs (+/-)-3-chloro-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide (2), (+/-)-N-(4-cyano-3-(trifluoro-methyl)phenyl)-2-methyloxirane-2-carboxamide (3), (+/-)-4-fluorophenylsulfonyl-2-hydroxy-2-methylpropionic acid (4) and (+/-)-3-hydroxy-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide (5). The methods involved the use of a cellulose-based Chiralcel OD-H, macrocyclic glycopeptide-based Chirobiotic T, TAG and R, beta-cyclodextrin-based Cyclobond I 2000SN and t-butyl carbamate-derivatized quinine-based columns. The conditions affording the best resolution were found by selection and variation of the mobile-phase compositions, and the differences in separation capability of the methods were noted. The sequence of elution of the enantiomers was determined in all cases.

MATERIAIS
Número do produto
Marca
Descrição do produto

Supelco
Coluna de HPLC quiral Astec® CHIROBIOTIC® T, 5 μm particle size, L × I.D. 25 cm × 4.6 mm
Supelco
Astec® CYCLOBOND I 2000 Chiral HPLC Column, 5 μm particle size, L × I.D. 25 cm × 4.6 mm
Supelco
Coluna de HPLC quiral Astec® CHIROBIOTIC® V, 5 μm particle size, L × I.D. 25 cm × 4.6 mm
Supelco
Astec® CHIROBIOTIC® TAG Chiral HPLC Column, 5 μm particle size, L × I.D. 25 cm × 4.6 mm
Supelco
Coluna de HPLC quiral Astec® CYCLOBOND I 2000 HP-RSP, 5 μm particle size, L × I.D. 25 cm × 4.6 mm
Supelco
Astec® CHIROBIOTIC® R Chiral HPLC Column, 5 μm particle size, L × I.D. 25 cm × 4.6 mm
Supelco
Astec® CHIROBIOTIC® R Chiral HPLC Column, 5 μm particle size, L × I.D. 15 cm × 4.6 mm
Supelco
Astec® CHIROBIOTIC® TAG Chiral HPLC Column, 5 μm particle size, L × I.D. 25 cm × 21.2 mm
Supelco
Astec® CHIROBIOTIC® R Chiral HPLC Column, 5 μm particle size, L × I.D. 15 cm × 2.1 mm
Supelco
Astec® CHIROBIOTIC® TAG Chiral HPLC Column, 5 μm particle size, L × I.D. 15 cm × 4.6 mm
Supelco
Coluna de HPLC quiral Astec® CYCLOBOND I 2000 HP-RSP, 5 μm particle size, L × I.D. 15 cm × 4.6 mm
Supelco
Coluna de HPLC quiral Astec® CHIROBIOTIC® T, 5 μm particle size, L × I.D. 15 cm × 4.6 mm
Supelco
Astec® CYCLOBOND I 2000 Chiral HPLC Column, 5 μm particle size, L × I.D. 25 cm × 10 mm
Supelco
Coluna de HPLC quiral Astec® CHIROBIOTIC® V, 5 μm particle size, L × I.D. 10 cm × 4.6 mm
Supelco
Astec® CHIROBIOTIC® R Chiral HPLC Column, 5 μm particle size, L × I.D. 10 cm × 4.6 mm
Supelco
Astec® CYCLOBOND I 2000 Chiral HPLC Column, 5 μm particle size, L × I.D. 15 cm × 2.1 mm
Supelco
Coluna de HPLC quiral Astec® CHIROBIOTIC® V, 5 μm particle size, L × I.D. 15 cm × 4.6 mm
Supelco
Coluna de HPLC quiral Astec® CHIROBIOTIC® T, 5 μm particle size, L × I.D. 5 cm × 4.6 mm
Supelco
Coluna de HPLC quiral Astec® CHIROBIOTIC® T, 5 μm particle size, L × I.D. 15 cm × 2.1 mm
Supelco
Coluna de HPLC quiral Astec® CHIROBIOTIC® T, 5 μm particle size, L × I.D. 25 cm × 10 mm
Supelco
Astec® CYCLOBOND I 2000 Chiral HPLC Column, 5 μm particle size, L × I.D. 10 cm × 2.1 mm
Supelco
Coluna de HPLC quiral Astec® CHIROBIOTIC® T, 5 μm particle size, L × I.D. 25 cm × 2.1 mm
Supelco
Coluna de HPLC quiral Astec® CHIROBIOTIC® T, 5 μm particle size, L × I.D. 10 cm × 2.1 mm
Supelco
Coluna de HPLC quiral Astec® CHIROBIOTIC® V, 5 μm particle size, L × I.D. 15 cm × 2.1 mm
Supelco
Astec® CHIROBIOTIC® TAG Chiral HPLC Column, 5 μm particle size, L × I.D. 25 cm × 2.1 mm
Supelco
Astec® CHIROBIOTIC® R Chiral HPLC Column, 5 μm particle size, L × I.D. 25 cm × 2.1 mm
Supelco
Coluna de HPLC quiral Astec® CHIROBIOTIC® T, 5 μm particle size, L × I.D. 10 cm × 4.6 mm
Supelco
Astec® CHIROBIOTIC® TAG Chiral HPLC Column, 5 μm particle size, L × I.D. 10 cm × 4.6 mm
Supelco
Astec® CHIROBIOTIC® TAG Chiral HPLC Column, 5 μm particle size, L × I.D. 25 cm × 10 mm
Supelco
Coluna de HPLC quiral Astec® CHIROBIOTIC® V, 5 μm particle size, L × I.D. 10 cm × 2.1 mm