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V900931

Sigma-Aldrich

Trichostatin A 

Vetec™, reagent grade, from Streptomyces sp., ≥98%

Sinônimo(s):

Trichostatin A, TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide

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About This Item

Fórmula empírica (Notação de Hill):
C17H22N2O3
Número CAS:
58880-19-6
Peso molecular:
302.37
Número MDL:
MFCD03848392
Código UNSPSC:
12352200
ID de substância PubChem:
329830233

fonte biológica

Streptomyces sp.

grau

reagent grade

linha de produto

Vetec™

Ensaio

≥98%

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

C[C@H](\C=C(C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C

InChI

1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1

chave InChI

RTKIYFITIVXBLE-QEQCGCAPSA-N

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Ações bioquímicas/fisiológicas

Trichostatin A (TSA) inhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression. May be involved in cell cycle progression of several cell types, inducing cell growth arrest at both G and G/M phases; may induce apoptosis. Enhances the efficacy of anticancer agents that target DNA. Trichostatin A serves as an epigenetic modifier.
Trichostatin A inhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression.

Informações legais

Vetec is a trademark of Merck KGaA, Darmstadt, Germany

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

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Certificados de análise (COA)

Lot/Batch Number
WXBD6126V
WXBD0920V
WXBC9796V
WXBC8885V
WXBC8514V

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