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N0636

Sigma-Aldrich

Nicotinamide

BioReagent, suitable for cell culture, suitable for insect cell culture

Sinônimo(s):

Niacinamide, Nicotinic acid amide, Pyridine-3-carboxylic acid amide, Vitamin B3, Vitamin PP

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About This Item

Fórmula empírica (Notação de Hill):
C6H6N2O
Número CAS:
98-92-0
Peso molecular:
122.12
Beilstein:
383619
Número CE:
202-713-4
Número MDL:
MFCD00006395
Código UNSPSC:
12352205
ID de substância PubChem:
24897434
NACRES:
NA.75

fonte biológica

synthetic (organic)

Nível de qualidade

200

linha de produto

BioReagent

Ensaio

≥98% (HPLC)

forma

powder

peso molecular

Mw 122.12 g/mol

técnica(s)

cell culture | insect: suitable
cell culture | mammalian: suitable

cor

white

pf

128-131 °C (lit.)

solubilidade

water: soluble 50 mg/mL, clear, colorless

cadeia de caracteres SMILES

NC(=O)c1cccnc1

InChI

1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

chave InChI

DFPAKSUCGFBDDF-UHFFFAOYSA-N

Informações sobre genes

human ... PARP1(142) , SIRT2(22933)

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Descrição geral

Nicotinamide (NAM) belongs to vitamin B family and is the amide form of vitamin B3. NAM is present in food and is a constituent of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). Tryptophan is the precursor for NAM synthesis in liver. NAM controls cell metabolism, redox reactions, mitochondrial functionsand energy generation. It promotes natural killer cells proliferation and survival. NAM confers neuroprotection and promotes neuronal maturation. It has the ability to cross the blood-brain barrier and may provide protection in ischaemic stroke and traumatic brain injury. NAM may elicit therapeutic benefits in Alzheimer′s, Parkinson′s, and Huntington′s diseases.

Aplicação

Nicotinamide has been used as a medium supplement in organoid culture of intestinal stem cells, esophageal squamous cell carcinomas(ESCC), pancreatic cancer organoids and pancreatic progenitor induction.

Ações bioquímicas/fisiológicas

Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H319

Classificações de perigo

Eye Irrit. 2

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

302.0 °F - closed cup

Ponto de fulgor (°C)

150 °C - closed cup

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

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Sigma-Aldrich

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Nicotinamide (Vitamin B3) solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

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Nicotinamide British Pharmacopoeia (BP) Reference Standard

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Sigma-Aldrich

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Sigma-Aldrich

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N0600000

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Nicotinamide (Niacinamide) analytical standard

Supelco

47865-U

Nicotinamide (Niacinamide)

Nicotinic acid BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥98%

Sigma-Aldrich

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Niacinamide meets USP testing specifications

Sigma-Aldrich

N5535

Niacinamide

Three-dimensional organoids reveal therapy resistance of esophageal and oropharyngeal squamous cell carcinoma cells
Kijima T, et al.
Cellular and molecular gastroenterology and hepatology, 7(1), 73-91 (2019)
Nicotinamide: Mechanism of action and indications in dermatology
Bains P, et al.
Indian Journal of Dermatology, Venereology and Leprology, 84(2), 234-237 (2018)
Nicotinamide, a form of vitamin B3, promotes expansion of natural killer cells that display increased in vivo survival and cytotoxic activity
Frei GM, et al.
Blood, 118, 4035-4035 (2011)
The influence of nicotinamide on health and disease in the central nervous system
Fricker RA, et al.
International Journal of Tryptophan Research : IJTR, 11, 1178646918776658-1178646918776658 (2018)
Rapid prototyping of a multilayer microphysiological system for primary human intestinal epithelial culture
Hosic S, et al.
bioRxiv, 400721-400721 (2018)
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