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B5887

Sigma-Aldrich

Sodium butyrate

≥98.5% (GC)

Sinônimo(s):

Butyric acid sodium salt

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About This Item

Fórmula linear:
CH3CH2CH2COONa
Número CAS:
156-54-7
Peso molecular:
110.09
Beilstein:
3629439
Número CE:
205-857-6
Número MDL:
MFCD00002816
Código UNSPSC:
12352107
ID de substância PubChem:
24891873
NACRES:
NA.25

fonte biológica

synthetic (organic)

Nível de qualidade

200

Ensaio

≥98.5% (GC)

Formulário

powder

condição de armazenamento

(Tightly closed. Dry.
Keep in a dry place. )

técnica(s)

DNA amplification: suitable
cell based assay: suitable
inhibition assay: suitable

cor

white

pf

250-253 °C (lit.)

solubilidade

water: 100 mg/mL, clear to slightly hazy, colorless

traços de cátion

Na: 19.8-22.0% (anhydrous)

adequação

suitable for DNA precipitation

aplicação(ões)

cell analysis
life science and biopharma
lipidomics

temperatura de armazenamento

room temp

cadeia de caracteres SMILES

[Na+].CCCC([O-])=O

InChI

1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1

chave InChI

MFBOGIVSZKQAPD-UHFFFAOYSA-M

Informações sobre genes

mouse ... ENSMUSG00000061062(15181)

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Aplicação

Sodium butyrate has been used:
  • as a component in homogenization and immunoprecipitation buffer for HDAC inhibition in fly embryos and insect s2 cells.
  • as histone deacetylase inhibitor in breast cancer cell line MDA-MB-231, analysed by cell viability assay and viral replication assay.
  • to enhance the production of recombinant tissue-plasminogen activator (t-PA) in Chinese hamster ovary (CHO) cells in a bioreactor.

Ações bioquímicas/fisiológicas

Sodium butyrate is a short-chain fatty acid that inhibits histone deacetylase (HDAC) in the millimolar range. Decreases Ca2+ release from intracellular stores. Induces apoptosis in several cell lines. Sodium butyrate induces the production of recombinant protein in Chinese hamster ovary (CHO) cells and other human cell lines. Sodium butyrate affects the proteome and gene expression pathways in the cells. It represses cell cycle related genes and modifies the genes involved in cell metabolism and apoptosis.

Atenção

Hygroscopic

Outras notas

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Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H302,H315,H319

Classificações de perigo

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
SLCK5357
SLCG7206
SLBQ8041V
SLBL2659V
091M5302V

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Histone deacetylase Rpd3 regulates olfactory projection neuron dendrite targeting via the transcription factor Prospero
Tea JS, et al.
The Journal of Neuroscience, 30(29), 9939-9946 (2010)
Na-butyrate sustains energetic states of metabolism and t-PA productivity of CHO cells
McMurray-Beaulieu V, et al.
Journal of Bioscience and Bioengineering, 108(2), 160-167 (2009)
Histone deacetylase inhibitors improve the replication of oncolytic herpes simplex virus in breast cancer cells
Cody JJ, et al.
PLoS ONE, 9(3), e92919-e92919 (2014)
Jiangping He et al.
Nature communications, 10(1), 34-34 (2019-01-04)
The majority of mammalian genomes are devoted to transposable elements (TEs). Whilst TEs are increasingly recognized for their important biological functions, they are a potential danger to genomic stability and are carefully regulated by the epigenetic system. However, the full
Joanna Jaworska et al.
Molecular neurobiology, 56(9), 6341-6370 (2019-02-16)
Neonatal hypoxic-ischemic (HI) brain injury likely represents the major cause of long-term neurodevelopmental disabilities in surviving babies. Despite significant investigations, there is not yet any known reliable treatment to reduce brain damage in suffering infants. Our recent studies in an
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