V8879

Vincristine sulfate salt

95.0-105.0% (HPLC), powder or crystals

• Sinônimo(s): 22-Oxovincaleukoblastine sulfate salt, Leurocristine sulfate salt, VCR
• Fórmula empírica (Notação de Hill): C₄₆H₅₆N₄O₁₀ · H₂SO₄
• Número CAS: 2068-78-2
• Peso molecular: 923.04
• Beilstein: 3924631
• Número CE: 218-190-0
• Número MDL: MFCD00084729
• Código UNSPSC: 51111767
• ID de substância PubChem: 57654729
• NACRES: NA.85

Propriedades

• fonte biológica: Streptomyces roseosporus
• Ensaio: 95.0-105.0% (HPLC)
• Formulário: powder or crystals
• condição de armazenamento: (Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
• cor: white to light yellow
• espectro de atividade do antibiótico: neoplastics
• Modo de ação: protein synthesis | interferes
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: OS(O)(=O)=O.CC[C@]1(O)CC2CN(CCc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C=O)C7[C@](O)([C@H](OC(C)=O)[C@]8(CC)C=CCN9CC[C@]67C89)C(=O)OC)C1
• InChI: 1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1
• chave InChI: AQTQHPDCURKLKT-PNYVAJAMSA-N

Descrição

Aplicação

Vincristine is an antitumor alkaloid isolated from Vinca Rosea. It is used to treat acute leukaemia, malignant lymphoma, Hodgkin′s disease, acute erythraemia, acute panmyelosis, breast cancer, Kaposi′s sarcoma and testicular cancer. Vincristine is widely used in cancer research. It is used to study multi-drug resistance. It is used to inhibit cell cycle progression at M-phase and to inhibit monoamine oxidase (MAO) .

Ações bioquímicas/fisiológicas

Vincristine is a plant alkaloid that inhibits microtubule assembly by binding tubulin and inducing coiled spiral aggregate formation. It arrests cell cycle in G2/M-phase by blocking mitotic spindle formation. Vincristine triggers Raf-1 activation, phosphorylation of bcl-2-family proteins, induction of p53 expression, and apoptosis in several tumor cell lines. It inhibits VEGF production in leukemia cell lines. It is a substrate for Pgp and CYP3A4. MRP1 transports vincristine in an ATP- and GSH-dependent manner. Vincristine has some immunosuppressant effect. Vincristine may also interfere with amino acid, cyclic AMP, and glutathione metabolism, calmodulin-dependent Ca2+-transport, cellular respiration, and nucleic acid and lipid biosynthesis.

Nota de análise

Freely soluble in water, Soluble in methanol, slightly soluble in ethanol

Outras notas

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Informações de segurança

• Pictogramas: GHS06,GHS08
• Palavra indicadora: Danger
• Frases de perigo: H300,H341,H361fd
• Declarações de precaução: P202 - P264 - P270 - P280 - P301 + P310 - P405
• Classificações de perigo: Acute Tox. 2 Oral - Muta. 2 - Repr. 2
• Código de classe de armazenamento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable