V8388

Vincristine sulfate

meets USP testing specifications

• Sinônimo(s): Vincristine sulfate salt, 22-Oxovincaleukoblastine sulfate salt, Leurocristine sulfate salt, VCR
• Fórmula empírica (Notação de Hill): C₄₆H₅₆N₄O₁₀ · H₂SO₄
• Número CAS: 2068-78-2
• Peso molecular: 923.04
• Beilstein: 3924631
• Número CE: 218-190-0
• Número MDL: MFCD00084729
• Código UNSPSC: 12352210
• ID de substância PubChem: 24900771
• NACRES: NA.21

Propriedades

• Agency: USP/NF; meets USP testing specifications
• Nível de qualidade: 200
• solubilidade: ethanol: slightly soluble; methanol: soluble; water: freely soluble
• espectro de atividade do antibiótico: neoplastics
• aplicação(ões): pharmaceutical (small molecule)
• Modo de ação: protein synthesis | interferes
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: OS(O)(=O)=O.CC[C@]1(O)CC2CN(CCc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C=O)C7[C@](O)([C@H](OC(C)=O)[C@]8(CC)C=CCN9CC[C@]67C89)C(=O)OC)C1
• InChI: 1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1
• chave InChI: AQTQHPDCURKLKT-PNYVAJAMSA-N

Descrição

Descrição geral

Vincristine sulfate is an alkaloid present in Cantharanthus roseus.

Aplicação

Vincristine sulfate has been used:

• as a positive control in potato disc anti-tumor bioassay
• as a standard cytotoxic agent
• to treat cells for manipulation of the microtubule network

Widely used in cancer research. In studies on multi-drug resistance. Used to inhibit cell cycle progression at M-phase. Used to inhibit monoamine oxidase (MAO).

Ações bioquímicas/fisiológicas

Vincristine sulfate possesses antitumor action targeting cell cycle. It prevents the action of tubulin by inhibiting microtubule polymerization. It also causes cell death and blocks metaphase in mitosis by preventing chromosome segregation. Vincristine sulfate inhibits angiogenesis mediated by factors such as vasculature endothelial growth factor. It decreases vascularization in tumors and normal tissues.

Informações de segurança

• Pictogramas: GHS06,GHS08
• Palavra indicadora: Danger
• Frases de perigo: H300,H341,H361fd
• Declarações de precaução: P202 - P264 - P270 - P280 - P301 + P310 - P405
• Classificações de perigo: Acute Tox. 2 Oral - Muta. 2 - Repr. 2
• Código de classe de armazenamento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)