T8516

Trifluoperazine dihydrochloride

≥99%, powder

• Sinônimo(s): 10-[3-(4-Methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine dihydrochloride
• Fórmula empírica (Notação de Hill): C₂₁H₂₄F₃N₃S · 2HCl
• Número CAS: 440-17-5
• Peso molecular: 480.42
• Beilstein: 3820024
• Número CE: 207-123-0
• Número MDL: MFCD00012656
• Código UNSPSC: 12352200
• ID de substância PubChem: 57654709
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥99%
• Formulário: powder
• cor: white to off-white
• pf: 243 °C (dec.) (lit.)
• solubilidade: ethanol: soluble 5 mg/mL; H₂O: soluble 50 mg/mL, clear, colorless to yellow; DMSO: soluble
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: Cl[H].Cl[H].CN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1
• InChI: 1S/C21H24F3N3S.2ClH/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24;;/h2-3,5-8,15H,4,9-14H2,1H3;2*1H
• chave InChI: BXDAOUXDMHXPDI-UHFFFAOYSA-N
• Informações sobre genes: human ... DRD2(1813) , DRD3(1814) , DRD4(1815) , HTR2A(3356) , HTR2C(3358)

Descrição

Aplicação

Trifluoperazine dihydrochloride has been used as a calmodulin kinase antagonist in cultured Aplysia californica neurons. Trifluoperazine dihydrochloride has also been used as a PMCA inhibitor in mouse duodenal tissues to block the transcellular active calcium flux.

Trifluoperazine dihydrochloride has been used:

• to inhibit clathrin-dependent endocytosis
• as a calmodulin kinase antagonist in cultured Aplysia californica neurons
• as a plasma membrane Ca²⁺-ATPase (PMCA) inhibitor in mouse duodenal tissues to block the transcellular active calcium flux

Ações bioquímicas/fisiológicas

Phenothiazine antipsychotic; D₂ dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.

Trifluoperazine dihydrochloride is useful in treating schizophrenia, disturbed behavior, severe anxiety, nausea and vomiting.

Características e benefícios

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota de preparo

Trifluoperazine dihydrochloride dissolves in water at 50 mg/ml, with heat as required, and yields a clear, colorless to yellow solution. It is also soluble in DMSO and ethanol (5 mg/ml).

Informações de segurança

• Pictogramas: GHS08,GHS07,GHS09
• Palavra indicadora: Danger
• Frases de perigo: H302,H319,H336,H341,H372,H410
• Declarações de precaução: P201 - P273 - P301 + P312 + P330 - P305 + P351 + P338 - P308 + P313
• Classificações de perigo: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Muta. 2 - STOT RE 1 - STOT SE 3
• Órgãos-alvo: Central nervous system, Eyes
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves