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T7455

Sigma-Aldrich

Tolvaptan

≥98% (HPLC), powder

Sinônimo(s):

N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide, OPC 41061

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About This Item

Fórmula empírica (Notação de Hill):
C26H25ClN2O3
Número CAS:
150683-30-0
Peso molecular:
448.94
Número MDL:
MFCD09838782
Código UNSPSC:
51111800
ID de substância PubChem:
329826866
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

forma

powder

cor

white to tan

solubilidade

DMSO: ≥15 mg/mL

originador

Sanofi Aventis

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

Cc1ccccc1C(=O)Nc2ccc(c(C)c2)C(=O)N3CCCC(O)c4cc(Cl)ccc34

InChI

1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31)

chave InChI

GYHCTFXIZSNGJT-UHFFFAOYSA-N

Informações sobre genes

human ... AVPR2(554)

Aplicação

Tolvaptan has been used as a V2-selective antagonist for studying its effect on hypertension in mice.

Ações bioquímicas/fisiológicas

Tolvaptan (OPC 41061) is a potent, orally active non-peptide vasopressin V2 selective antagonist. IC50 = 3 nM at the rat V2 receptor; 29 times more selective for the V2 than for V1a. Tolvaptan has also been shown to inhibit the development of polycystic kidney disease in several animal models.

Características e benefícios

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Nota de preparo

Tolvaptan is soluble in DMSO at a concentration that is greater than or equal to 15 mg/ml.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Sigma-Aldrich

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Vicente E Torres et al.
The New England journal of medicine, 367(25), 2407-2418 (2012-11-06)
The course of autosomal dominant polycystic kidney disease (ADPKD) is often associated with pain, hypertension, and kidney failure. Preclinical studies indicated that vasopressin V(2)-receptor antagonists inhibit cyst growth and slow the decline of kidney function. In this phase 3, multicenter
Hyponatremia and outcomes in patients with heart failure.
Steven R Goldsmith
Heart (British Cardiac Society), 98(24), 1761-1762 (2012-12-04)
[Vasopressin antagonist in hyponatremia. Rapid and simple control of serum sodium concentration].
MMW Fortschritte der Medizin, 154(22), 78-79 (2013-01-10)
Nicole K Littlejohn et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 304(10), R818-R828 (2013-03-29)
An indispensable role for the brain renin-angiotensin system (RAS) has been documented in most experimental animal models of hypertension. To identify the specific efferent pathway activated by the brain RAS that mediates hypertension, we examined the hypothesis that elevated arginine
Urine osmolality-guided tolvaptan therapy in decompensated heart failure.
Kaoru Dohi et al.
Circulation journal : official journal of the Japanese Circulation Society, 77(2), 313-314 (2012-12-28)
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