PHR1810

Tadalafil

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinônimo(s): Tadalafil
• Fórmula empírica (Notação de Hill): C₂₂H₁₉N₃O₄
• Número CAS: 171596-29-5
• Peso molecular: 389.40
• Código UNSPSC: 41116107
• NACRES: NA.24

Propriedades

• grau: certified reference material; pharmaceutical secondary standard
• Nível de qualidade: 300
• Agency: traceable to Ph. Eur. Y0001417; traceable to USP 1642879
• família API: tadalafil
• forma: powder
• Certificado de análise (CofA): current certificate can be downloaded
• embalagem: pkg of 500 mg
• técnica(s): HPLC: suitable; gas chromatography (GC): suitable
• aplicação(ões): pharmaceutical (small molecule)
• temperatura de armazenamento: 2-30°C
• InChI: 1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1
• chave InChI: WOXKDUGGOYFFRN-IIBYNOLFSA-N

Descrição

Descrição geral

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Tadalafil is a phosphodiesterase type 5 inhibitor that prevents the hydrolysis of cyclic adenosine monophosphate and cyclic guanosine monophosphate.

Aplicação

This pharmaceutical secondary standard can also be used as follows:

• Square-wave voltammetric (SWV) determination of tadalafil in pharmaceutical samples using a boron-doped diamond electrode (BDDE)
• Development of multi-walled and vertically oriented carbon nanotubes (voMWCNT) based electrochemical sensor for the detection of tadalafil in pharmaceutical samples
• Simultaneous determination of sildenafil, tadalafil, and vardenafil in pharmaceutical preparations by a high-temperature gas chromatography/mass spectrometry (HTGC/MS) method
• Development and validation of spectrophotometric methods for the combined analysis of dapoxetine hydrochloride and tadalafil in bulk and pharmaceutical dosage forms
• Spectrophotometric quantification of tamsulosin hydrochloride and tadalafil in their combined pharmaceutical preparation, following International Conference on Harmonization (ICH) guidelines

Nota de análise

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAB8867 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H315,H319,H335
• Declarações de precaução: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classificações de perigo: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable