SRP6505
G6PD human
recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
Sinônimo(s):
Glucose-6-phosphate 1-dehydrogenase, Zwf
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About This Item
Código UNSPSC:
12352204
NACRES:
NA.32
Produtos recomendados
fonte biológica
human
recombinante
expressed in E. coli
Ensaio
≥95% (SDS-PAGE)
forma
liquid
peso molecular
61.4 kDa (515 aa, 1- 515 aa)
embalagem
pkg of 100 μg
concentração
0.5 mg/mL
nº de adesão UniProt
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
Informações sobre genes
human ... G6PD(2539)
Descrição geral
G6PD (glucose-6-phosphate dehydrogenase) gene is mapped to human chromosome Xq28, and spans 16.2kb. One G6PD monomer is composed of 515 amino acids with a predicted molecular weight of 59,256Da. The active enzyme exists as a dimer, and contains an NADP molecule tightly bound to it.
Ações bioquímicas/fisiológicas
G6PD (glucose-6-phosphate dehydrogenase) enzyme catalyzes the oxidation of glucose-6-phosphate to 6-phosphogluconolactone, reducing NADP to NADPH. It therefore, catalyzes the first step of hexose monophosphate pathway (HMP). As it is responsible for the oxidation of glucose-6-phosphate, and thus, confers protection against oxidative damage in erythrocytes. Its deficiency is highly heterogenous, with around 190 variants being reported. The deficiency of G6PD was discovered while studying hemolytic anemia. G6PD also results in hereditary nonspherocytic hemolytic anemia.
forma física
0.5 mg/mL solution in 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1 mM PMSF, 2 mM EDTA, 2 mM DTT, 200 mM NaCl.
Nota de análise
The biological activity is > 7 units/ml obtained by measuring the increase of NADPH in absorbance at 340 nm resulting from the reduction of NAD or NADP. One unit oxidizes 1.0 μmole D-glucose-6-phosphate to 6-phospho-Dgluconate per min in the presence of beta-NADP at pH 7.4 at 25 °C.
Palavra indicadora
Warning
Frases de perigo
Declarações de precaução
Classificações de perigo
Eye Irrit. 2 - Skin Irrit. 2
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
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G6PD deficiency.
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Blood, 84(11), 3613-3636 (1994-12-01)
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