SML2981

EN219

≥98% (HPLC)

• Sinônimo(s): 1-(3,5-bis(4-Bromophenyl)-4,5-dihydro-1H-pyrazol-1-yl)-2-chloroethanone, 3,5-bis(4-Bromophenyl)-1-(chloroacetyl)-4,5-dihydro-1H-pyrazole
• Fórmula empírica (Notação de Hill): C₁₇H₁₃Br₂ClN₂O
• Número CAS: 380351-29-1
• Peso molecular: 456.56
• Número MDL: MFCD02989881
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: white to beige
• solubilidade: DMSO: 2 mg/mL, clear
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: Brc1ccc(cc1)C2N(NC(=C2)c3ccc(cc3)Br)C(=O)CCl
• chave InChI: PREWPJFURADJST-UHFFFAOYSA-N

Descrição

Ações bioquímicas/fisiológicas

EN219 is a cell-permeable chloroacetamide compound that selectively inhibits E3 ligase RNF114-mediated autoubiquitination and p21 ubiquitination. EN219 is shown to covalently interact with RNF114-C8 (IC50 = 470 nM), TUBB1-C201, HSPD1-C442, and HIST1H3A-C97. EN219 is a recruiter of the E3 ubiquitin ligase RNF114 that can be utilized for PROTAC applications.

cell-permeable chloroacetamide compound that selectively inhibits E3 ligase RNF114-mediated autoubiquitination and p21 ubiquitination

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable