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A8523

Sigma-Aldrich

Amoxicillin

95.0-102.0% anhydrous basis

Sinônimo(s):

Amoxicillin anhydrous, D-(-)-α-Amino-p-hydroxybenzyl penicillin

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About This Item

Fórmula empírica (Notação de Hill):
C16H19N3O5S
Número CAS:
26787-78-0
Peso molecular:
365.40
Beilstein:
7507120
Número CE:
248-003-8
Número MDL:
MFCD00056860
Código UNSPSC:
51102829
ID de substância PubChem:
329770960
NACRES:
NA.85

Nível de qualidade

200

Ensaio

95.0-102.0% anhydrous basis

Formulário

powder

espectro de atividade do antibiótico

Gram-negative bacteria
Gram-positive bacteria

Modo de ação

cell wall synthesis | interferes

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccc(O)cc3)C(=O)N2[C@H]1C(O)=O

InChI

1S/C16H19N3O5S/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24)/t9-,10-,11+,14-/m1/s1

chave InChI

LSQZJLSUYDQPKJ-NJBDSQKTSA-N

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Categorias relacionadas

Descrição geral

Chemical structure: ß-lactam

Aplicação

Amoxicillin is used to study the oxygen dependent antimicrobial systems of polymorphonuclear leukocytes (PMNLs), the risk of resistance development in Helicobacter pylori, and various dosing strategies against Streptococcus pneumoniae and Pneumococcal pneumonia . It is also used to study the synthesis of bacterial cell walls at the level of peptidoglycan polymer chain cross-linking involving bacterial transpeptidase.

Ações bioquímicas/fisiológicas

Amoxicillin is a broad-spectrum, β-lactam antibiotic. It is a 4-hydroxy analog of ampicillin with similar ranges of actions and utility to ampicillin. Amoxicillin inhibits the cross-linkage between linear peptidoglycan polymer chains that are the major component of both Gram-positive and Gram-negative bacteria.

Outras notas

Keep container tightly closed in a dry and well-ventilated place.

Pictogramas

Health hazard
GHS08

Palavra indicadora

Danger

Frases de perigo

H317,H334

Classificações de perigo

Resp. Sens. 1 - Skin Sens. 1

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
0000145334
0000130503
108M4891V
108M4892V
098M4779V

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Clarithromycin ≥95% (HPLC)

Sigma-Aldrich

C9742

Clarithromycin

Amoxicillin impurity standard British Pharmacopoeia (BP) Reference Standard

BP748

Amoxicillin impurity standard

Clarithromycin 96.0-102.0% (HPLC)

Sigma-Aldrich

A3487

Clarithromycin

Ampicillin anhydrous, 96.0-102.0% (anhydrous basis)

Sigma-Aldrich

A9393

Ampicillin

Cephalexin Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1848

Cephalexin

Cefazolin sodium salt 89.1-110.1%

Sigma-Aldrich

C5020

Cefazolin sodium salt

Erythromycin BioReagent, suitable for cell culture

Sigma-Aldrich

E5389

Erythromycin

Sulfamethoxazole

Supelco

S7507

Sulfamethoxazole

M Sörberg et al.
Antimicrobial agents and chemotherapy, 42(5), 1222-1228 (1998-05-21)
We have studied initial killing, morphological alterations, the frequency of occurrence, and the selective growth of resistant subpopulations of Helicobacter pylori during exposure to amoxicillin, clarithromycin, or metronidazole by bioluminescence assay of intracellular ATP levels, microscopy, and a viable count
Jose-Manuel Rodriguez-Martinez et al.
Antimicrobial agents and chemotherapy, 54(1), 471-476 (2009-11-18)
Two carbapenem-resistant isolates, one Escherichia coli isolate and one Klebsiella pneumoniae isolate, recovered from an Algerian patient expressed a novel VIM-type metallo-beta-lactamase (MBL). The identified bla(VIM-19) gene was located on a ca. 160-kb plasmid and located inside a class 1
Raymond Cha et al.
The Journal of antimicrobial chemotherapy, 54(6), 1067-1071 (2004-10-16)
Beta-Lactam antimicrobials are dosed intermittently or continuously based on their short half-lives and concentration-independent activity. Based on the relationship between antimicrobial killing and bacterial growth cycle, the pharmacodynamics of a unique pulsatile strategy was investigated. In vitro pharmacodynamic models with
Thierry Naas et al.
Antimicrobial agents and chemotherapy, 52(4), 1257-1263 (2008-01-30)
Genetic structures surrounding the carbapenem-hydrolyzing Ambler class A bla KPC gene were characterized in several KPC-positive Klebsiella pneumoniae and Pseudomonas aeruginosa strains isolated from the United States, Colombia, and Greece. The bla KPC genes were associated in all cases with
Amélie Carrër et al.
Antimicrobial agents and chemotherapy, 54(3), 1369-1373 (2010-01-21)
Eighteen carbapenem-resistant, OXA-48-positive enterobacterial isolates recovered from Turkey, Lebanon, Egypt, France, and Belgium were analyzed. In most isolates, similar 70-kb plasmids carrying the carbapenemase gene bla(OXA-48) were identified. That gene was located within either transposon Tn1999 or transposon Tn1999.2, which
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