A3487

Clarithromycin

96.0-102.0% (HPLC)

• Sinônimo(s): 6-O-Methylerythromycin
• Fórmula empírica (Notação de Hill): C₃₈H₆₉NO₁₃
• Número CAS: 81103-11-9
• Peso molecular: 747.95
• Número MDL: MFCD00865140
• Código UNSPSC: 51102829
• ID de substância PubChem: 329770825
• NACRES: NA.85

Propriedades

• fonte biológica: synthetic
• Nível de qualidade: 200
• Ensaio: 96.0-102.0% (HPLC)
• Formulário: powder
• cor: white to off-white
• espectro de atividade do antibiótico: Gram-negative bacteria; Gram-positive bacteria
• Modo de ação: protein synthesis | interferes
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: O[C@@H]([C@@](O)(C)[C@@H](CC)OC([C@H](C)[C@H]1O[C@@H]2O[C@@H](C)[C@H](O)[C@](C)(OC)C2)=O)[C@@H](C)C([C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@H]1C)=O
• InChI: 1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1
• chave InChI: AGOYDEPGAOXOCK-KCBOHYOISA-N

Descrição

Aplicação

Clarithromycin has been used to study its effect on the potassium channel KCNJ5^WT.

Ações bioquímicas/fisiológicas

Clarithromycin is a macrolide antibiotic that interferes with bacterial protein synthesis. Clarithromycin is an acid-stable version of erythromycin and is particularly effective against Gram-negative bacteria. It has a short half-life, however its metabolite, 14-hydroxy clarithromycin is nearly twice as active as clarithromycin against certain bacteria.

Clarithromycin is stable in gastric acid.

Clarithromycin possess bactericidal activity including anti-mycobacterial activity against Mycobacterium leprae, and M.avium complex.

Embalagem

100mg

Nota de preparo

Practically insoluble in water, soluble in acetone and methylene chloride, slightly soluble in methanol.

Outras notas

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302
• Declarações de precaução: P301 + P312 + P330
• Classificações de perigo: Acute Tox. 4 Oral
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable