75199

Azithromycin

• Sinônimo(s): CP 62,993
• Fórmula empírica (Notação de Hill): C₃₈H₇₂N₂O₁₂
• Número CAS: 83905-01-5
• Peso molecular: 748.98
• Número MDL: MFCD00873574
• Código UNSPSC: 12352200
• ID de substância PubChem: 329766256
• NACRES: NA.77

Propriedades

• forma: powder
• Nível de qualidade: 200
• atividade óptica: [α]/D −45±2°, c = 1% in ethanol
• espectro de atividade do antibiótico: viruses
• aplicação(ões): environmental
• Modo de ação: protein synthesis | interferes
• cadeia de caracteres SMILES: CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O
• InChI: 1S/C38H72N2O12/c1-15-27-38(10,46)31(42)24(6)40(13)19-20(2)17-36(8,45)33(52-35-29(41)26(39(11)12)16-21(3)48-35)22(4)30(23(5)34(44)50-27)51-28-18-37(9,47-14)32(43)25(7)49-28/h20-33,35,41-43,45-46H,15-19H2,1-14H3/t20-,21-,22+,23-,24-,25+,26+,27-,28+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1
• chave InChI: MQTOSJVFKKJCRP-BICOPXKESA-N

Descrição

Descrição geral

Azithromycin is a hydrophobic azalide and a derivative of erythromycin. It belongs to the macrolide class of antibodies.

Aplicação

Azithromycin has been used:

• to treat synchronized Plasmodium falciparum Dd2 parasites for continuous growth assays to study the antiparasitic mechanisms of doxycycline (DOX)
• to study its bactericidal activity against Pseudomonas aeruginosa in combination with a recombinant hemolymph plasma lectin (rHPLOE)
• in evolution experiments to study P. aeruginosa strain PA14’s response to bacteriostatic antibiotics

Ações bioquímicas/fisiológicas

Azithromycin is a broad-spectrum antimicrobial agent, effective against infections associated with respiratory tract, skin, tissues, and genital chlamydia. It acts against Gram-negative bacteria (including Enterobacteriaceae) and several Gram-positive organisms. It also acts against Plasmodium falciparum and P. vivax, which are multidrug resistance species that transmit malaria. Azithromycin targets the plasmodial ribosome and prevents protein synthesis. It is soluble in lipids and metabolizes in the liver by undergoing demethylation. It is commonly used to treat community-acquired pneumonia, sexually transmitted diseases, acute otitis media, and acute exacerbation of chronic obstructive pulmonary disease (COPD).

Características e benefícios

• Rapidly absorbed
• Shows great tissue penetration and procures high intracellular concentration
• Distributes widely in body fluids and tissues

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Informações de segurança

• Pictogramas: GHS08,GHS09
• Palavra indicadora: Danger
• Frases de perigo: H317,H334,H410
• Declarações de precaução: P261 - P272 - P273 - P280 - P284 - P302 + P352
• Classificações de perigo: Aquatic Chronic 1 - Resp. Sens. 1 - Skin Sens. 1
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Faceshields, Gloves, type N95 (US)