SML1664

Deoxynivalenol Ready Made Solution

1 mg/mL

• Sinônimo(s): (3α,7α)-3,7,15-trihydroxy-12,13-epoxytrichothec-9-en-8-one, 4-Deoxynivalenol, DON, Dehydronivalenol, RD-toxon, Vomitoxin
• Fórmula empírica (Notação de Hill): C₁₅H₂₀O₆
• Número CAS: 51481-10-8
• Peso molecular: 296.32
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• fonte biológica: Fusarium sp. (Fusarium asiaticum)
• Nível de qualidade: 200
• Formulário: solution (ethanol: 2-propanol 95:5)
• condição de armazenamento: protect from light
• concentração: 1 mg/mL
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: O1[C@]2([C@@H]3O[C@H]4[C@@]([C@]2(C[C@H]3O)C)([C@@H](C(=O)C(=C4)C)O)CO)C1
• InChI: 1S/C15H20O6/c1-7-3-9-14(5-16,11(19)10(7)18)13(2)4-8(17)12(21-9)15(13)6-20-15/h3,8-9,11-12,16-17,19H,4-6H2,1-2H3/t8-,9-,11-,12-,13-,14-,15+/m1/s1
• chave InChI: LINOMUASTDIRTM-QGRHZQQGSA-N

Descrição

Ações bioquímicas/fisiológicas

Deoxynivalenol (DON) is a trichothecene mycotoxin that inhibits the synthesis of DNA and RNA as well as protein synthesis at the ribosomal level.

Deoxynivalenol (DON) is a trichothecene mycotoxin that inhibits the synthesis of DNA and RNA as well as protein synthesis at the ribosomal level. DON induces IL-6 mediated serum hyperelevation of IgA, as well as phosphorylation of extracellular signal regulated protein kinases 1 and 2 (ERK 1,2) and c-Jun N-terminal kinases 1 and 2 (JNK 1,2) in mice. An in vitro study with porcine ovarian granulosa cells suggests a dose dependent association of DON on porcine ovarian functions. It was also shown that LPS and its downstream mediators can interact with DON to modulate proliferative, cytotoxic and apoptotic outcomes in leukocytes in a tissue specific manner.

Nota de preparo

Deoxynivalenol ready-made solution (1 mg/ml in Ethanol: 2-propanol 95:5) can be diluted in aqueous buffers to a working concentration of 0.1-1 μg/ml (1:1000).

Informações de segurança

• Pictogramas: GHS02,GHS07
• Palavra indicadora: Danger
• Frases de perigo: H225,H319
• Declarações de precaução: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Classificações de perigo: Eye Irrit. 2 - Flam. Liq. 2
• Código de classe de armazenamento: 3 - Flammable liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): 57.2 °F
• Ponto de fulgor (°C): 14 °C