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Documentos Principais

SML1018

Sigma-Aldrich

Cyclosporin A

≥95% (HPLC), DMSO solution, calcineurin inhibitor

Sinônimo(s):

CsA, Cyclosporine

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About This Item

Fórmula empírica (Notação de Hill):
C62H111N11O12
Número CAS:
59865-13-3
Peso molecular:
1202.61
Número CE:
200-664-3
Código UNSPSC:
12352200
NACRES:
NA.77

Nome do produto

Cyclosporin A, Ready Made Solution, 1 mg/mL in DMSO

Formulário

DMSO solution

Nível de qualidade

200

condição de armazenamento

protect from light

concentração

1 mg/mL in DMSO

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

N1(C(C(=O)NC(C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C1=O)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C)CC)C(O)C(C\C=C\C)C)C

InChI

1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+

chave InChI

PMATZTZNYRCHOR-IMVLJIQESA-N

Aplicação

Cyclosporin A has been used to test its toxic effect on perfused 3D proximal tubule model.

Ações bioquímicas/fisiológicas

Cyclosporin A is a non-polar cyclic oligopeptide produced by the fungus Tolypocladium inflatum. It is a potent immunosuppressive agent, affecting primarily T-lymphocytes.
Cyclosporin A is a non-polar cyclic oligopeptide produced by the fungus Tolypocladium inflatum. It is a potent immunosuppressive agent, affecting primarily T-lymphocytes. It has been shown to inhibit the functioning of several nuclear proteins involved in T-cell activation at the level of mRNA transcription. It forms a complex with its intracellular receptor cyclophilin, which can then bind to calcineurin, a Ca2+- and calmodulin-dependent protein phosphatase, inhibiting its enzymatic activity. CsA was found to suppress the replication of hepatitis C virus genome in cultured hepatocytes. At concentrations >10 nM, CsA protected isolated hepatocytes against the action of phalloidin. CsA can inhibit IL2 production resulting from T cell activation via Calcineurin inhibition.
An extensive list of references has been reported, including a comprehensive review of analytical properties.
Cyclosporin A is generally given subsequent to transplant surgery to prevent rejection. In addition to its beneficial effects in organ transplantation, cyclosporin (CyA) exhibits nephrotoxic side effects.

Outras notas

Light sensitive

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

188.6 °F - closed cup

Ponto de fulgor (°C)

87 °C - closed cup

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Certificados de análise (COA)

Lot/Batch Number
056M4104V
115M4183V
11160423
11151021
114M4036V

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