D8428

Decorin from bovine articular cartilage

salt-free, lyophilized powder, sterile-filtered

• Número MDL: MFCD00283027
• Código UNSPSC: 12352202
• NACRES: NA.75

Propriedades

• fonte biológica: bovine articular cartilage
• Nível de qualidade: 200
• esterilidade: sterile-filtered
• forma: salt-free, lyophilized powder
• peso molecular: ~100 kDa
• embalagem: glass bottle of 0.5 mg
• técnica(s): cell culture | mammalian: suitable
• solubilidade: PBS: ≥2.00 mg/mL, clear, colorless to yellow
• nº de adesão UniProt: P21793
• temperatura de armazenamento: −20°C
• Informações sobre genes: cow ... DCN(280760)

Descrição

Descrição geral

Decoran is a small proteoglycan composed of a chondroitin/dermatan sulfate glycosaminoglycans attached to a 40 kDa core protein. It is found primarily in the extracellular matrix of articular cartilage. Decorin interacts with collagen types I and II via its core protein wherein it delays fibrillogenesis. Decorin also interacts with fibronectin, thrombospondin and TGF-β isoforms, and the EGF-receptor.

Decorin from bovine articular cartilage is a proteoglycan that belongs to the small leucine-rich repeat proteoglycans and proteins (SLRPs) family. Decorin is present in almost all tissues. It has a protein core composed of leucine-rich repeats (LRRs), flanked by two cysteine-rich regions.

Aplicação

Decorin from bovine articular cartilage has been used in solid phase binding assay (ELISA), binding assays, binding inhibition assay, parasite binding assays, scaffold fabrication, quartz crystal microbalance assay, inhibition of CSA (chondroitin sulphate A) binding assay and glycans and glycan biotinylation.

Ações bioquímicas/fisiológicas

Decorin plays an important role in guiding the proper assembly of collagen during fibrillogenesis. Deficiency in decorin results in altered tissue structure and function. It controls growth factors like EGF and TGF-β. Decorin blocks aggregation of fibrils into fibers and fibrillogenesis in cell-free constructs of polymerized type I collagen.

Outras notas

Decorin is an approx. 100 kDa proteoglycan consisting of a 40 kDa core protein and one chondroitin or dermatan sulfate glycosaminoglycan chain.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)