30024

Cyclosporin A

97.0-101.5% (on dried basis)

• Sinônimo(s): Antibiotic S 7481F1, Cyclosporine
• Fórmula empírica (Notação de Hill): C₆₂H₁₁₁N₁₁O₁₂
• Número CAS: 59865-13-3
• Peso molecular: 1202.61
• Beilstein: 3647785
• Número MDL: MFCD00274558
• Código UNSPSC: 51102829
• ID de substância PubChem: 57648402
• NACRES: NA.76

Propriedades

• Nível de qualidade: 200
• Ensaio: 97.0-101.5% (on dried basis)
• Formulário: powder
• cor: white to off-white
• espectro de atividade do antibiótico: fungi
• Modo de ação: enzyme | inhibits
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C
• InChI: 1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1
• chave InChI: PMATZTZNYRCHOR-CGLBZJNRSA-N
• Informações sobre genes: human ... PPIA(5478)

Descrição

Descrição geral

Chemical structure: peptide

Aplicação

Cyclosporin A is used for immunosuppressive studies .

Ações bioquímicas/fisiológicas

A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.

Potent immunosuppressant; inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα; blocks cytochrome c release from mitochondria.

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Outras notas

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.Storage class (TRGS 510): Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects.

Informações de segurança

• Pictogramas: GHS08,GHS07
• Palavra indicadora: Danger
• Frases de perigo: H302,H350,H360FD
• Declarações de precaução: P201 - P202 - P264 - P270 - P301 + P312 - P308 + P313
• Classificações de perigo: Acute Tox. 4 Oral - Carc. 1B - Repr. 1B
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Equipamento de proteção individual: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges