SML0091

L-Dopa ethyl ester

≥98% (HPLC)

• Sinônimo(s): 3,4-Dihydroxy-L-phenylalanine ethyl ester, 3-Hydroxy-L-tyrosine ethyl ester, Etilevodopa, L-Dopa ethyl ester, L-Dopa-Et, Levodopa ethyl ester, O-Ethyl-DOPA, TV-1203
• Fórmula empírica (Notação de Hill): C₁₁H₁₅NO₄
• Número CAS: 37178-37-3
• Peso molecular: 225.24
• Número MDL: MFCD00871210
• Código UNSPSC: 12352108
• ID de substância PubChem: 329825151

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• forma: powder
• atividade óptica: [α]/D +15 to +19°, c = 1 in methanol ([α]/D)
• cor: white to tan
• solubilidade: H₂O: ≥12 mg/mL at warmed to 60 °C
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: CCOC(=O)[C@@H](N)Cc1ccc(O)c(O)c1
• InChI: 1S/C11H15NO4/c1-2-16-11(15)8(12)5-7-3-4-9(13)10(14)6-7/h3-4,6,8,13-14H,2,5,12H2,1H3/t8-/m0/s1
• chave InChI: NULMGOSOSZBEQL-QMMMGPOBSA-N
• Informações sobre genes: human ... DRD3(1814)

Descrição

Aplicação

L-Dopa ethyl ester has been used to study the protective effects of piperlongumine (PLG) on rotenone-induced Parkinson disease (PD).

Ações bioquímicas/fisiológicas

L-Dopa ethyl ester (L-Dopa) is a dopamine replacement drug. It is used as a potent therapeutic for Parkinson disease (PD). L-Dopa has some long-term side effects, such as the deterioration of motor function.

L-Dopa ethyl ester is a prodrug of levodopa that has greater gastric solubility. The drug is rapidly hydrolyzed to levodopa by nonspecific esterases in the gastrointestinal tract. L-Dopa ethyl ester (etilevodopa)-carbidopa treatment was well tolerated but did not demonstrate better efficacy compared with standard levodopa-carbidopa treatment. L-Dopa ethyl ester should have a significant brain penetration following an administration by injection.

Características e benefícios

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302 - H319
• Declarações de precaução: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
• Classificações de perigo: Acute Tox. 4 Oral - Eye Irrit. 2
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable