H2380

6-Hydroxy-DL-DOPA

≥98% (HPLC), powder, APE1 inhibitor

• Sinônimo(s): 2,4,5-Trihydroxy-DL-phenylalanine, 2,5-Dihydroxy-DL-tyrosine
• Fórmula empírica (Notação de Hill): C₉H₁₁NO₅
• Número CAS: 21373-30-8
• Peso molecular: 213.19
• Beilstein: 2860065
• Número MDL: MFCD00004272
• Código UNSPSC: 12352200
• ID de substância PubChem: 24278464
• NACRES: NA.32

Propriedades

• Nome do produto: 6-Hydroxy-DL-DOPA, ≥98% (HPLC), powder
• Nível de qualidade: 200
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: off-white
• solubilidade: H₂O: 3 mg/mL; 1 M HCl: 50 mg/mL (Solutions should be freshly prepared and protected from exposure to light.)
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: NC(Cc1cc(O)c(O)cc1O)C(O)=O
• InChI: 1S/C9H11NO5/c10-5(9(14)15)1-4-2-7(12)8(13)3-6(4)11/h2-3,5,11-13H,1,10H2,(H,14,15)
• chave InChI: YLKRUSPZOTYMAT-UHFFFAOYSA-N

Descrição

Descrição geral

Dissolve in oxygen-free boiled water containing 0.1% sodium metabisulfite or other antioxidant. Solutions should be freshly prepared and protected from exposure to light.

Ações bioquímicas/fisiológicas

6-Hydroxy-DL-DOPA is an inhibitor of APE1 (apurinic/apyrimidinic endonuclease) repair-function activity. APE1 is a nuclease crucial for DNA base excision repair pathway. 6-Hydroxy-DL-DOPA also blocks RAD52 (DNA repair protein) single-stranded DNA binding domain.

Precursor of the catecholaminergic neurotoxin, 6-hydroxydopamine; converted to 6-hydroxydopamine by L-aromatic amino acid decarboxylase.

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Atenção

Hygroscopic; photosensitive

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)