SMB00289
Diallyl trisulfide
≥98% (HPLC)
Sinônimo(s):
Allyl trisulfide, Di-2-propenyl trisulfide
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About This Item
Fórmula empírica (Notação de Hill):
C6H10S3
Número CAS:
Peso molecular:
178.34
Número CE:
Número MDL:
Código UNSPSC:
12352200
ID de substância PubChem:
NACRES:
NA.25
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Nível de qualidade
Ensaio
≥98% (HPLC)
Formulário
oil
aplicação(ões)
metabolomics
vitamins, nutraceuticals, and natural products
temperatura de armazenamento
−20°C
cadeia de caracteres SMILES
C=CCSSSCC=C
InChI
1S/C6H10S3/c1-3-5-7-9-8-6-4-2/h3-4H,1-2,5-6H2
chave InChI
UBAXRAHSPKWNCX-UHFFFAOYSA-N
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Descrição geral
Diallyl trisulfide (DATS) is one of the organosulfur compounds found in garlic (Allium sativum), and other Allium genera such as onions. This sulfur-rich compound is produced by the rapid disintegration of its metabolic precursor Allicin.
Aplicação
Diallyl trisulfide (DATS) has been used to study its antimicrobial effects against Campylobacter jejuni. It has also been used to test its effect on hepatic regeneration in partial hepatectomy (PHx) rats.
Ações bioquímicas/fisiológicas
Diallyl trisulfide (DATS) is a potent anti-cancer and chemopreventive agent that regulates apoptosis, metastasis, cell cycle, and angiogenesis in cancer pathways. It is also an excellent neuroprotective agent. DATS elicits antioxidant and anti-inflammatory activities against doxorubicin (DOX)-induced rats brains. It may improve glycemic control, muscle glucose utilization, and insulin secretion in streptozotocin-induced diabetic rats.
Palavra indicadora
Danger
Frases de perigo
Declarações de precaução
Classificações de perigo
Acute Tox. 3 Oral
Código de classe de armazenamento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Cheng-Tzu Liu et al.
European journal of pharmacology, 516(2), 165-173 (2005-06-07)
We investigated the effects of garlic oil and diallyl trisulfide on glycemic control in rats with streptozotocin-induced diabetes. Diabetic rats received by gavage garlic oil (100 mg/kg body weight), diallyl trisulfide (40 mg/kg body weight), or corn oil every other
Wai-Shing Leung et al.
Free radical biology & medicine, 160, 141-148 (2020-08-04)
Doxorubicin (DOX) is a widely used antitumor drug that causes severe neurotoxicity in patients. Diallyl trisulfide (DATS) is an organosulfur compound with established potent antioxidant and anti-inflammatory properties. Herein, we investigated the neuroprotective efficacy of DATS in preventing DOX-induced neurotoxicity
Enhanced hepatocyte survival and anti-apoptosis via Akt by Diallyl trisulfide, augments hepatic regeneration through hydrogen sulfide in partially hepatectomized rats
Nithyananthan S, et al.,
Phytomedicine Plus, 1(4), 100048-100048 (2021)
Meng-Meng Sun et al.
Neurological research, 31(1), 23-27 (2008-09-05)
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease, selectively involving the upper and lower motor neurons. Glutamate excitotoxicity and oxidative stress are important mechanisms for the pathogenesis of ALS. Nuclear-factor erythroid 2-related factor 2 (Nrf2) is a master transcriptional
Diallyl trisulfide inhibits proliferation, invasion and angiogenesis of glioma cells by inactivating Wnt/β-catenin signaling.
Tao Q, et al.
Cell and Tissue Research, 370(3), 379-390 (2017)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SMB00289-100MG | 4061837076350 |
| SMB00289-500MG |
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