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SMB00577

Sigma-Aldrich

Diallyl trisulfide

≥97% (HPLC)

Sinônimo(s):

Allyl trisulfide, Di-2-propenyl trisulfide

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About This Item

Fórmula empírica (Notação de Hill):
C6H10S3
Número CAS:
2050-87-5
Peso molecular:
178.34
Número CE:
218-107-8
Número MDL:
MFCD00040025
Código UNSPSC:
12352200
ID de substância PubChem:
329825066
NACRES:
NA.25

fonte biológica

Allium sativum L.

Nível de qualidade

200

Ensaio

≥97% (HPLC)

forma

liquid

aplicação(ões)

metabolomics
vitamins, nutraceuticals, and natural products

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

C=CCSSSCC=C

InChI

1S/C6H10S3/c1-3-5-7-9-8-6-4-2/h3-4H,1-2,5-6H2

chave InChI

UBAXRAHSPKWNCX-UHFFFAOYSA-N

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Descrição geral

Diallyl trisulfide (DATS) is one of the stable naturally occurring bioactive polysulfide compounds found in Allium vegetables, especially in garlic.

Aplicação

Diallyl trisulfide (DATS) has been used as an exogenous hydrogen sulfide (H2S)donor to study the effects on proliferation, apoptosis, and autophagy of human urothelial carcinoma (UC) cells in vitro.

Ações bioquímicas/fisiológicas

Diallyl trisulfide elicits cardioprotective and anti-metabolic syndrome (MetS) effects against ex vivo induced myocardial ischemia/reperfusion (I/R) injury in MetS rats (male Wistar albino). It is a potent anti-cancer agent and acts by modulating different cancer-related pathways, inducing cell cycle arrest, apoptosis, metastasis, and angiogenesis in in vitro studies. DATS is also an effective therapeutic agent against multidrug resistance in triple-negative breast cancer (TNBC). DATS and its nanoemulsions display high antifungal activity against wood-rotting fungi such as T. hirsuta and L. sulphureus. It also provides protection against brain damage induced by ischemia/reperfusion (I/R) by activating nuclear factor erythroid 2-related factor 2 (Nrf2) in rat brains.

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H301

Declarações de precaução

P264 - P270 - P301 + P310 - P405 - P501

Classificações de perigo

Acute Tox. 3 Oral

Código de classe de armazenamento

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Sigma-Aldrich

74264

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S-Allyl-L-cysteine ≥98% (HPLC)

Sigma-Aldrich

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Sigma-Aldrich

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Elisabetta Panza et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 151, 113137-113137 (2022-05-24)
The role of H2S in urothelial carcinoma (UC) is still unclear. Here we have evaluated the expression of H2S producing enzymes as well as the effect of endogenous and exogenous H2S on human bladder UC cells. In human UC cells
Carlos A Silva-Islas et al.
Antioxidants (Basel, Switzerland), 8(9) (2019-09-22)
Stroke is a public health problem due to its high mortality and disability rates; despite these, the pharmacological treatments are limited. Oxidative stress plays an important role in cerebral damage in stroke and the activation of the nuclear factor erythroid

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