S8626

Sulfadiazine

99.0-101.0%

• Sinônimo(s): 4-Amino-N-(2-pyrimidinyl)benzenesulfonamide, N¹-(Pyrimidin-2-yl)sulfanilamide
• Fórmula empírica (Notação de Hill): C₁₀H₁₀N₄O₂S
• Número CAS: 68-35-9
• Peso molecular: 250.28
• Beilstein: 6733588
• Número CE: 200-685-8
• Número MDL: MFCD00006065
• Código UNSPSC: 51283908
• ID de substância PubChem: 24899802
• NACRES: NA.85

Propriedades

• descrição: Solubility - Practically insoluble in water, slightly soluble in acetone, very slightly soluble in ethanol (96 per cent). It dissolves in solutions of alkali hydroxides and in dilute mineral acids.
• Nível de qualidade: 200
• Ensaio: 99.0-101.0%
• Formulário: powder or crystals
• cor: white to faint yellow, faint pink
• pf: 253 °C (dec.) (lit.)
• solubilidade: 96% ethanol: very slightly soluble; acetone: slightly soluble; water: practically insoluble
• espectro de atividade do antibiótico: Gram-negative bacteria; Gram-positive bacteria; mycoplasma
• Modo de ação: DNA synthesis | interferes; enzyme | inhibits
• cadeia de caracteres SMILES: Nc1ccc(cc1)S(=O)(=O)Nc2ncccn2
• InChI: 1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14)
• chave InChI: SEEPANYCNGTZFQ-UHFFFAOYSA-N

Descrição

Descrição geral

Chemical structure: sulfonamide

Aplicação

Sulfadiazine is a short-acting sulfonamide that is commonly used with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome. It is also used to treat newborns with congenital infections. Sulfadiazine has been used to control acute infections when studying murine models of reactivated toxoplasmosis.

Ações bioquímicas/fisiológicas

Sulfadiazine is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfadiazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

Outras notas

Keep container tightly closed in a dry and well-ventilated place.Storage class (TRGS 510): Non Combustible Solids

Informações de segurança

• Pictogramas: GHS08,GHS07,GHS09
• Palavra indicadora: Warning
• Frases de perigo: H302,H361d,H411
• Declarações de precaução: P202 - P264 - P273 - P280 - P301 + P312 - P308 + P313
• Classificações de perigo: Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 2
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Faceshields, Gloves