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Key Documents

PHR1343

Supelco

Sulfadiazine

Pharmaceutical Secondary Standard; Certified Reference Material

Sinônimo(s):

Sulfadiazine, 4-Amino-N-(2-pyrimidinyl)benzenesulfonamide, N1-(Pyrimidin-2-yl)sulfanilamide

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About This Item

Fórmula empírica (Notação de Hill):
C10H10N4O2S
Número CAS:
Peso molecular:
250.28
Beilstein:
6733588
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de substância PubChem:
NACRES:
NA.24

grau

certified reference material
pharmaceutical secondary standard

Nível de qualidade

Agency

traceable to Ph. Eur. S1800000
traceable to USP 1625009

família API

sulfadiazine

Certificado de análise (CofA)

current certificate can be downloaded

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

pf

253 °C (dec.) (lit.)

aplicação(ões)

pharmaceutical (small molecule)

formato

neat

temperatura de armazenamento

2-30°C

cadeia de caracteres SMILES

Nc1ccc(cc1)S(=O)(=O)Nc2ncccn2

InChI

1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14)

chave InChI

SEEPANYCNGTZFQ-UHFFFAOYSA-N

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Descrição geral

Sulfadiazine is a bacteriostatic drug, that belongs to the class of medication referred as sulfonamide antibiotics. It is generally used in the treatment of cerebral meningitis, pneumonia, staphylococcal and streptococcal sepsis.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Aplicação

Sulfadiazine may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by high performance liquid chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Nota de análise

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Outras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAC3953 in the slot below. This is an example certificate only and may not be the lot that you receive.

Palavra indicadora

Warning

Frases de perigo

Classificações de perigo

Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 2

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 2


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Pharmacopeia, US
United States Pharmacopeia/National Formulary, 4106-4106 (2018)
Sulfonamide antibiotics
Connor EE
Primary Care Update for OB/GYNS, 5(1), 32-35 (1998)
33 - Antimicrobial Drugs
Synthesis of Essential Drugs, 499-523 (2006)
Determination of the content and the related substances of silver sulfadiazine gel by HPLC
Li Y, et al.
Chinese Journal of Hospital Pharmacy, 24(8), 474-474 (2004)
Simultaneous determination of enrofloxacin, silver sulfadiazine, hydrocortisone acetate, hydrocortisone sodium succinate, and preservative excipients in pharmaceutical preparations using HPLC-DAD method
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