S0383

Sulfameter

• Sinônimo(s): 5-Methoxysulfadiazine, N¹-(5-Methoxypyrimidin-2-yl)sulfanilamide, Sulfamethoxydiazine
• Fórmula empírica (Notação de Hill): C₁₁H₁₂N₄O₃S
• Número CAS: 651-06-9
• Peso molecular: 280.30
• Beilstein: 621130
• Número CE: 211-480-8
• Número MDL: MFCD00006067
• Código UNSPSC: 51283913
• ID de substância PubChem: 24899422
• NACRES: NA.85

Propriedades

• forma: powder
• condição de armazenamento: (Keep container tightly closed in a dry and well-ventilated place. Light sensitive.)
• cor: white to faint yellow
• espectro de atividade do antibiótico: Gram-negative bacteria; Gram-positive bacteria; mycobacteria; parasites
• Modo de ação: enzyme | inhibits
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: COc1cnc(NS(=O)(=O)c2ccc(N)cc2)nc1
• InChI: 1S/C11H12N4O3S/c1-18-9-6-13-11(14-7-9)15-19(16,17)10-4-2-8(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15)
• chave InChI: GPTONYMQFTZPKC-UHFFFAOYSA-N

Descrição

Descrição geral

Chemical structure: sulfonamide

Aplicação

Sulfameter is a sulfonamide antibiotic used as a leprostatic agent and to treat urinary tract infections. It has been investigated as a potential therapy for chloroquine-resistant malaria during pregnancy.

Ações bioquímicas/fisiológicas

Sulfameter is a sulfonamide antibiotic. Sulfonamides block the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfonamides are competitive inhibitors of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. Sulfameter is a dihydrofolate reductase (DHFR) inhibitor. Sulfonamides are active against Gram positive bacteria and Gram negative bacteria. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

Outras notas

Keep container tightly closed in a dry and well-ventilated place. Light sensitive.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H315,H319,H335
• Declarações de precaução: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classificações de perigo: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves