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Merck
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Documentos Principais

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S7007

Supelco

Sulfadimethoxine

98.0-102.0%

Sinônimo(s):

4-Amino-N-(2,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide

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About This Item

Fórmula empírica (Notação de Hill):
C12H14N4O4S
Número CAS:
122-11-2
Peso molecular:
310.33
Beilstein:
306856
Número CE:
204-523-7
Número MDL:
MFCD00057345
Código UNSPSC:
41116107
ID de substância PubChem:
329824574
NACRES:
NA.24

Nível de qualidade

200

Ensaio

98.0-102.0%

Formulário

powder

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

espectro de atividade do antibiótico

Gram-negative bacteria
Gram-positive bacteria

aplicação(ões)

forensics and toxicology
pharmaceutical (small molecule)

Modo de ação

DNA synthesis | interferes
enzyme | inhibits

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

COc1cc(NS(=O)(=O)c2ccc(N)cc2)nc(OC)n1

InChI

1S/C12H14N4O4S/c1-19-11-7-10(14-12(15-11)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16)

chave InChI

ZZORFUFYDOWNEF-UHFFFAOYSA-N

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Descrição geral

Chemical structure: sulfonamide

Aplicação

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Ações bioquímicas/fisiológicas

Sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase.
Mode of Action: Inhibits folic acid synthesis in prokaryotes.
Anti-microbial Spectrum: Gram positive, Gram negative, Chlamydia
Mode of Resistance: Alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H302

Declarações de precaução

P264 - P270 - P301 + P312 - P501

Classificações de perigo

Acute Tox. 4 Oral

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
059M4032V
088M4031V
038M4043V
117M4061V
067M4054V

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Annie von Eyken et al.
Journal of the American Society for Mass Spectrometry, 30(5), 765-777 (2019-03-17)
Non-targeted screening (e.g., suspected-target) is emerging as an attractive tool to investigate the occurrence of contaminants in food. The sample preparation and instrument analysis steps are known to influence the identification of analytes with non-targeted workflows, especially for complex matrices.
Silvia Gazzin et al.
Pediatric research, 71(6), 653-660 (2012-02-18)
Few data exist on regional brain bilirubin content in the neonatal period when acute bilirubin-induced neurologic damage (BIND) may occur, and no information is available on regional brain expression of cytochrome P450 monooxygenases (Cyps) that oxidize bilirubin. Bilirubin content was
Masamichi Nakayama et al.
Colloids and surfaces. B, Biointerfaces, 99, 12-19 (2011-10-07)
Diblock copolymer comprising thermoresponsive poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide) (PIPAAm-co-DMAAm) and hydrophobic poly(benzyl methacrylate) blocks was prepared by reversible addition-fragmentation chain transfer radical polymerization. Terminal functionalization of thermoresponsive blocks with either pH-responsive sulfadimethoxine (SD) or hydroxyl groups was performed through coupling reactions with thiol
Kyung-Mi Song et al.
Biosensors & bioelectronics, 33(1), 113-119 (2012-01-17)
A polymer-based aptasensor, which consisted of fluorescein amidite (FAM)-modified aptamers and coordination polymer nanobelts (CPNBs), was developed utilizing the fluorescence quenching effect to detect sulfadimethoxine residue in food products. A single-stranded DNA (ssDNA) aptamer, which was a specific bio-probe for
Dan Liu et al.
Chemical & pharmaceutical bulletin, 59(1), 63-71 (2011-01-08)
Recently, dendrimers have been widely used in medical applications such as drug delivery and gene transfection. In this study, a pH-sensitive diblock copolymer of poly(methacryloyl sulfadimethoxine) (PSD) and polyethylene glycol (PEG) modified by lactose (LA-PEG-b-PSD) was synthesized. The pK(a) value
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