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S4776

Sigma-Aldrich

Somatotropin from human pituitary

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), lyophilized powder

Sinônimo(s):

Growth Hormone, STH

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About This Item

Número MDL:
MFCD00081960
Código UNSPSC:
51111800
NACRES:
NA.32

recombinante

expressed in E. coli

Nível de qualidade

200

esterilidade

non-sterile

Ensaio

≥95% (SDS-PAGE)

forma

lyophilized powder

potência

0.025-0.1 ng/mL cell proliferation using Nb2-11 cells per bioactivity ED50

peso molecular

predicted mol wt ~22 kDa

drug control

Home Office Schedule 4.2

Impurezas

endotoxin, tested

solubilidade

PBS: 0.100 mL, clear, colorless (with 0.1% BSA )

nº de adesão UniProt

P01241
P10912

Condições de expedição

ambient

temperatura de armazenamento

−20°C

Informações sobre genes

human ... GH1(2688) , GHR(2690)

Descrição geral

Somatotropin or growth hormone is a peptide hormone that is secreted by the anterior pituitary gland. It is essential for growth. The hormone increases muscle mass, reduces fat mass, helps in maintaining normal blood glucose levels and also promotes a balanced lipid profile.

Aplicação

Somatotropin or growth hormone has been used to study the molecular interactions of ephrin type-A receptor 4 precursor (EphA4) with the growth hormone receptor. It has also been used to induce differentiation in mammary epithelial cell line HC11.

Ações bioquímicas/fisiológicas

Increases mass of most tissues by increasing cell number rather than cell size, mobilizes fat stores.

forma física

Lyophilized from a 0.2 μm filtered solution in TBS (20 mM Tris, 0.15 M NaCl, pH 8.5) containing 50 μg of BSA per 1 μg of cytokine.

Reconstituição

It is recommended that sterile PBS containing at least 0.1% human serum albumin or bovine serum albumin be added to the vial to prepare a stock solution of no less than 10 μg/mL.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Molecular interactions of EphA4, growth hormone receptor, Janus kinase 2, and signal transducer and activator of transcription 5B
Takahiro Sawada
PLoS ONE (2017)
Somatotropin in the treatment of growth hormone deficiency and Turner syndrome in pediatric patients: a review
Christina Southern Reh
Clinical Pharmacology & Biopharmaceutics (2010)
Lina Pednekar et al.
Frontiers in immunology, 7, 600-600 (2017-01-10)
Dendritic cells (DCs) are the most potent antigen-presenting cells capable of priming naïve T-cells. Its C-type lectin receptor, DC-SIGN, regulates a wide range of immune functions. Along with its role in HIV-1 pathogenesis through complement opsonization of the virus, DC-SIGN
Quantitative analysis of the expression of whey acidic protein (WAP) mRNA in the prolactin-responsive mouse mammary gland epithelial cell line, HC11
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Journal of Reproduction and Development (2001)
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