S4441

D,L-Sulforaphane

≥90% (HPLC), liquid, phase II detoxification enzymes inducer

• Sinônimo(s): 1-Isothiocyanato-4-(methylsulfinyl)-butane
• Fórmula empírica (Notação de Hill): C₆H₁₁NOS₂
• Número CAS: 4478-93-7
• Peso molecular: 177.29
• Número MDL: MFCD00198068
• Código UNSPSC: 12352200
• ID de substância PubChem: 24724610
• NACRES: NA.77

Propriedades

• product name: DL-Sulforaphane, ≥90% (HPLC), synthetic, liquid
• fonte biológica: synthetic
• Nível de qualidade: 200
• Ensaio: ≥90% (HPLC)
• forma: liquid
• solubilidade: DMSO: soluble 40 mg/mL; H₂O: insoluble
• compatibilidade: for use with ABI 7500
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: CS(=O)CCCCN=C=S
• InChI: 1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3
• chave InChI: SUVMJBTUFCVSAD-UHFFFAOYSA-N

Descrição

Aplicação

LNCaP prostate cancer cells were treated with DL-Sulforaphane to study the effect on androgen receptor. Effects on malathion toxicity was studied in rats by treating them with DL-Sulforaphane.

Ações bioquímicas/fisiológicas

Selective inducer of phase II detoxification enzymes with anticarcinogenic properties. Organosulfur compound found in cruciferous vegetables, including broccoli.

Sulforaphane is an anti-cancer, anti-microbial and anti-diabetic compound found in cruciferous vegetables. It induces the production of detoxifying enzymes such as quinone reductase and glutathione S-transferase that cause xenobiotic transformation. Sulforaphane also increases the transcription of tumor suppressor proteins and inhibits histone deacetylases. It modulates inflammatory responses by suppressing the LPS-mediated expression of iNOS, COX-2, IL-1β and TNF-α.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 3
• Equipamento de proteção individual: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)