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R8781

Sigma-Aldrich

Rapamycin

from Streptomyces hygroscopicus, ≥95% (HPLC), solution, mTOR inhibitor

Sinônimo(s):

23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine solution

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About This Item

Fórmula empírica (Notação de Hill):
C51H79NO13
Peso molecular:
914.17
Número CE:
200-664-3
Código UNSPSC:
12352200
NACRES:
NA.77

Nome do produto

Rapamycin, Ready Made Solution, 2.5 mg/mL in DMSO (2.74 mM), from Streptomyces hygroscopicus

fonte biológica

Streptomyces hygroscopicus

Nível de qualidade

300

pressão de vapor

0.56 hPa ( 20 °C)

Ensaio

≥95% (HPLC)

Formulário

solution

temperatura de autoignição

301 °C

concentração

2.5 mg/mL in DMSO (2.74 mM)

cor

colorless to yellow

espectro de atividade do antibiótico

fungi
yeast

Modo de ação

enzyme | inhibits

temperatura de armazenamento

−20°C

Categorias relacionadas

Descrição geral

Rapamycin is a macrocyclic triene antibiotic possessing potent immunosuppressant and anticancer activity. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. The effectors of mTOR action include 4EBP1 and S6K1.
Rapamycin, an mTOR inhibitor, is derived from Streptomyces hygroscopicus. It can inhibit viral replication. This natural anti-fungal antibiotic is a proven anti-aging agent. Rapamycin significantly inhibits mTORC1 regardless of age.

Aplicação

Rapamycin has been used:
  • as a supplement in mTeSR1 medium to culture induced pluripotent stem cell (iPSC) colonies for induction of autophagy signaling
  • to treat the Drosophila S2 cells at 65-70% confluence,
  • to measure protein synthesis
  • to stimulate autophagy in ovarian cancer cells

Embalagem

200uL

Outras notas

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research
Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. Is Hygroscopic.
Rapamycin has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the Rapamycin probe summary on the Chemical Probes Portal website.

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

188.6 °F - closed cup

Ponto de fulgor (°C)

87 °C - closed cup

Equipamento de proteção individual

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
11181131
118M4155V
11180805
087M4106V
11170316

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