Q3251

Quinacrine dihydrochloride

≥90% (TLC), powder, MAO-A/B inhibitor

• Sinônimo(s): 6-Chloro-9-(4-diethylamino-1-methylbutylamino)-2-methoxyacridine dihydrochloride, Atebrin dihydrochloride, Mepacrine dihydrochloride
• Fórmula empírica (Notação de Hill): C₂₃H₃₀ClN₃O · 2HCl
• Número CAS: 69-05-6
• Peso molecular: 472.88
• Beilstein: 4834013
• Número CE: 200-700-8
• Número MDL: MFCD00012659
• Código UNSPSC: 12352101
• ID de substância PubChem: 24278192
• NACRES: NA.77

Propriedades

• Nome do produto: Quinacrine dihydrochloride, ≥90%
• fonte biológica: synthetic
• Ensaio: ≥90%
• Formulário: powder
• pf: 257 °C
• solubilidade: H₂O: soluble, clear to hazy
• originador: Bayer
• cadeia de caracteres SMILES: Cl[H].Cl[H].CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc3ccc(OC)cc13
• InChI: 1S/C23H30ClN3O.2ClH/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23;;/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);2*1H
• chave InChI: UDKVBVICMUEIKS-UHFFFAOYSA-N
• Informações sobre genes: human ... MAOA(4128) , MAOB(4129)

Descrição

Descrição geral

Quinacrine is an acridine derivative and a potent antimalarial agent.

Aplicação

Quinacrine dihydrochloride has been used:

• in its uptake and accumulation studies in mouse lung slices using fluorescence microscope
• in the staining of ATP vesicles in mesenchymal stem cells (MSCs)
• in uptake-release assay for characterization of dense granule functionality of platelets

Ações bioquímicas/fisiológicas

Non-selective MAO-A/B inhibitor.

Quinacrine has anthelmintic functionality and used in the female sterilization. It is used to treat systemic lupus erythematosus and rheumatic diseases. Apart from malaria, Quinacrine is effective for treating giardia and tapeworm infections. It inhibits nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity in addition to monoamine oxidase inhibition.

Características e benefícios

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Armazenamento e estabilidade

Stock solutions are stable for up to 60 h at 20°C.

Outras notas

This product is not assigned an expiration date or recommended retest date.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302
• Declarações de precaução: P264 - P270 - P301 + P312 - P501
• Classificações de perigo: Acute Tox. 4 Oral
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves