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P7130

Sigma-Aldrich

Puromycin aminonucleoside

Sinônimo(s):

3′-Amino-3′-deoxy-N6,N6-dimethyladenosine

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About This Item

Fórmula empírica (Notação de Hill):
C12H18N6O3
Número CAS:
58-60-6
Peso molecular:
294.31
Beilstein:
93902
Número CE:
200-388-3
Número MDL:
MFCD00063462
Código UNSPSC:
51281912
ID de substância PubChem:
24898823
NACRES:
NA.85

forma

powder

Nível de qualidade

300

solubilidade

H2O: soluble 50 mg/mL

espectro de atividade do antibiótico

Gram-positive bacteria
neoplastics
parasites

Modo de ação

protein synthesis | interferes

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CN(C)c1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@H](N)[C@@H]3O

InChI

1S/C12H18N6O3/c1-17(2)10-8-11(15-4-14-10)18(5-16-8)12-9(20)7(13)6(3-19)21-12/h4-7,9,12,19-20H,3,13H2,1-2H3/t6-,7+,9+,12-/m1/s1

chave InChI

RYSMHWILUNYBFW-VENHTOENSA-N

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Descrição geral

Puromycin aminonucleoside is the aminonucleoside portion of the antibiotic puromycin. It is useful in nephrology research, like studies of focal and segmental glomerulosclerosis and in the induction of nephrosis in rats. The excretion of sodium and nitrite (NOx) metabolites in rats with puromycin aminonucleoside-induced nephrotic syndrome are studied. Puromycin aminonucleoside-induced nephrosis in rats has been studied with respect to the production of reactive oxygen species during the acute phase. Puromycin aminonucleoside is used to probe endothelial glycosaminoglycan synthesis in cultured glomerular endothelial cells and their relation to cell permeability.

Aplicação

Puromycin aminonucleoside has been used:
  • as a selection marker for the infected cells for the transfection of lentivirus
  • as a component of fresh medium for transfection and infection assays
  • to subcutaneously induce puromycin aminonucleoside nephrosis to investigate the mRNA and protein levels of nephrin and podocin before the onset of proteinuria

Ações bioquímicas/fisiológicas

Puromycin aminonucleoside is used to study human glomerular disease by inducing damage of murine glomerular podocytes and is used to study glomerular function and morphology.

Outras notas

Keep container tightly closed in a dry and well-ventilated place.

Pictogramas

Health hazard
GHS08

Palavra indicadora

Warning

Frases de perigo

H373

Classificações de perigo

STOT RE 2

Órgãos-alvo

Kidney

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

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The Journal of pathology, 247(2), 177-185 (2018-10-24)
Dynamin plays an essential role in maintaining the structure and function of the glomerular filtration barrier. Specifically, dynamin regulates the actin cytoskeleton and the turnover of nephrin in podocytes, and knocking down dynamin expression causes proteinuria. Moreover, promoting dynamin oligomerization
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Scientific reports, 10(1), 9419-9419 (2020-06-12)
Dominant and recessive mutations in podocalyxin (PODXL) are associated with human kidney disease. Interestingly, some PODXL mutations manifest as anuria while others are associated with proteinuric kidney disease. PODXL heterozygosity is associated with adult-onset kidney disease and podocalyxin shedding into
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Gene expression differs substantially among individual cells of the same type. We speculate that genes that are expressed in all but a portion of cells of a given cell type would be likely essential and required for either the cell
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Microarrays allow for the simultaneous measurement of changes in the levels of thousands of messenger RNAs within a single experiment. As such, the potential for the application of transcription profiling to preclinical safety assessment and mechanism-based risk assessment is profound.
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To show the three-dimensional distribution of proteins in renal cells, we applied the immunogold scanning electron microscopy method using vibratome slices. Kidney specimens from puromycin aminonucleoside (PAN) nephrotic rats and controls were obtained after intravenous infusion of human serum albumin
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