SBR00017
Puromycin aminonucleoside Ready Made Solution
10 mg/mL in water
Sinônimo(s):
3′-Amino-3′-deoxy-N6,N6-dimethyladenosine
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About This Item
Fórmula empírica (Notação de Hill):
C12H18N6O3
Número CAS:
Peso molecular:
294.31
Código UNSPSC:
51281912
NACRES:
NA.85
Produtos recomendados
Ensaio
≥98%
Nível de qualidade
Formulário
liquid
concentração
10 mg/mL in water
espectro de atividade do antibiótico
Gram-positive bacteria
neoplastics
parasites
Modo de ação
protein synthesis | interferes
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
N[C@H]1[C@@H](O)[C@H](N(C=N2)C3=C2C(N(C)C)=NC=N3)O[C@@H]1CO
InChI
1S/C12H18N6O3/c1-17(2)10-8-11(15-4-14-10)18(5-16-8)12-9(20)7(13)6(3-19)21-12/h4-7,9,12,19-20H,3,13H2,1-2H3
chave InChI
RYSMHWILUNYBFW-UHFFFAOYSA-N
Categorias relacionadas
Ações bioquímicas/fisiológicas
Puromycin aminonucleoside is an aminonucleoside derivative of the known antibiotic puromycin. Puromycin aminonucleoside has been used in nephrology research, studying focal and segmental glomerulosclerosis, and in the induction of nephrosis in rats. Rats with puromycin aminonucleoside-induced nephrotic syndrome were used to study the excretion of sodium and NOx metabolites.
Puromycin aminonucleoside has also been used to probe endothelial glycosaminoglycan synthesis in cultured glomerular endothelial cells and their relation to cell permeability. A puromycin aminonucleoside nephrosis model of rat glomerular disease was also used to study the role of the neuron-specific ubiquitin C-terminal hydrolase protein gene product 9.5 (PGP 9.5).
Puromycin aminonucleoside has also been used to probe endothelial glycosaminoglycan synthesis in cultured glomerular endothelial cells and their relation to cell permeability. A puromycin aminonucleoside nephrosis model of rat glomerular disease was also used to study the role of the neuron-specific ubiquitin C-terminal hydrolase protein gene product 9.5 (PGP 9.5).
Nota de preparo
Puromycin aminonucleoside solution is provided at 10 mg/mL in water and could be further diluted in aqueous buffers to a working concentration of 10 μg/mL (1:1000).
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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