P5248
Etidronate disodium hydrate
≥97% (NMR), solid
Sinônimo(s):
Dihydrogen (1-hydroxyethylidene)bisphosphonate disodium hydrate
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About This Item
Fórmula empírica (Notação de Hill):
C2H6Na2O7P2 · xH2O
Número CAS:
Peso molecular:
249.99 (anhydrous basis)
Número CE:
Número MDL:
Código UNSPSC:
12352200
ID de substância PubChem:
NACRES:
NA.77
Produtos recomendados
Nível de qualidade
Ensaio
≥97% (NMR)
Formulário
solid
cor
white
pf
>300 °C
solubilidade
H2O: ≥10 mg/mL
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
[Na+].[Na+].CC(O)(P(O)([O-])=O)P(O)([O-])=O
InChI
1S/C2H8O7P2.2Na/c1-2(3,10(4,5)6)11(7,8)9;;/h3H,1H3,(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2
chave InChI
GWBBVOVXJZATQQ-UHFFFAOYSA-L
Categorias relacionadas
Aplicação
Etidronate disodium hydrate has been used in the synthesis of bisphosphonate derivatives of adenosine triphosphate (ATP)by T4 RNA ligase. It has also been sued to inhibit human farnesyl diphosphate synthase (FDPS).
Ações bioquímicas/fisiológicas
Bisphosphonate antiresorptive agent. Less potent inhibitor of farnesyl diphosphate synthase (IC50 = 80 μM) as compared to the nitrogen containing bisphosphonates
Etidronate helps to guard chronic ocular hypertension prompted retinal oxidative stress. It stimulates the development of retinal ganglion cells through insulin-like growth factor 1 (IGF-1) signaling pathway. It may possess neuroprotective effects in in vivo and in vitro rat model of glaucoma. Etidronate belongs to bisphosphonates.
Palavra indicadora
Warning
Frases de perigo
Declarações de precaução
Classificações de perigo
Acute Tox. 4 Oral
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
dust mask type N95 (US), Eyeshields, Gloves
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