PHR1764

Colchicina

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinônimo(s): (S)-N-(5,6,7,9-tetraidro-1,2,3,10-tetrametoxi-9-oxobenzo[a]heptalen-7-il)acetamida
• Fórmula empírica (Notação de Hill): C₂₂H₂₅NO₆
• Número CAS: 64-86-8
• Peso molecular: 399.44
• Beilstein: 2228813
• Número CE: 200-598-5
• Número MDL: MFCD00078484
• Código UNSPSC: 41116107
• ID de substância PubChem: 329823598
• NACRES: NA.24

Propriedades

• grau: certified reference material; pharmaceutical secondary standard
• Nível de qualidade: 300
• Agency: traceable to BP 1150; traceable to Ph. Eur. C2580000; traceable to USP 1146006
• família API: colchicine, thiocolchicoside
• Certificado de análise (CofA): current certificate can be downloaded
• embalagem: pkg of 400 mg
• técnica(s): HPLC: suitable; gas chromatography (GC): suitable
• pf: 150-160 °C (dec.) (lit.)
• aplicação(ões): pharmaceutical (small molecule)
• Formato: neat
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: COC1=CC=C2C(=CC1=O)[C@H](CCc3cc(OC)c(OC)c(OC)c23)NC(C)=O
• InChI: 1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
• chave InChI: IAKHMKGGTNLKSZ-INIZCTEOSA-N
• Informações sobre genes: human ... TUBA1A(7846) , TUBA1B(10376) , TUBA1C(84790) , TUBA3C(7278) , TUBA3E(112714) , TUBA4A(7277) , TUBB(203068) , TUBB1(81027) , TUBB2A(7280) , TUBB2B(347733) , TUBB3(10381) , TUBB4A(10382) , TUBB4B(10383) , TUBB6(84617) , TUBB8(347688)

Descrição

Descrição geral

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Colchicine is a drug used for the treatment of gout and certain rheumatic and nonrheumatic conditions. It is the major alkaloid in the plant Colchicum autumnale (meadow saffron).

Aplicação

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Colchicine may be used as a pharmaceutical reference standard for the determination of colchicine in human plasma at therapeutic concentrations by liquid chromatography–tandem mass spectrometry method.

Informações de segurança

• Pictogramas: GHS06,GHS08
• Palavra indicadora: Danger
• Frases de perigo: H300,H340
• Declarações de precaução: P202 - P264 - P280 - P301 + P310 - P405 - P501
• Classificações de perigo: Acute Tox. 2 Oral - Muta. 1B
• Código de classe de armazenamento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable