Pular para o conteúdo
Merck
Todas as fotos(1)

Key Documents

View All Documentation

10295892001

Roche

Colcemid

solution, suitable for blocking, sterile; 0.2 μm filtered

Sinônimo(s):

Demecolcine, N-Deacetyl-N-methylcolchicine

Faça loginpara ver os preços organizacionais e de contrato
Todas as fotos(1)

About This Item

Fórmula empírica (Notação de Hill):
C21H25NO5
Número CAS:
477-30-5
Peso molecular:
371.43
Beilstein:
2822892
Número MDL:
MFCD00075459
Código UNSPSC:
12352207
ID de substância PubChem:
329749009

descrição

N-methyl-N-deacetyl-colchicine

Nível de qualidade

100

esterilidade

sterile; 0.2 μm filtered

forma

solution

embalagem

pkg of 20 mL (10 μg/ml)

fabricante/nome comercial

Roche

técnica(s)

blocking: suitable

Impurezas

microbial, tested

solubilidade

water: miscible

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CN[C@H]1CCc2cc(OC)c(OC)c(OC)c2C3=CC=C(OC)C(=O)C=C13

InChI

1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3/t15-/m0/s1

chave InChI

NNJPGOLRFBJNIW-HNNXBMFYSA-N

Procurando produtos similares? Visita Guia de comparação de produtos

Categorias relacionadas

Descrição geral

Colcemid is also known as demecolcine. Its generic name is N-methyl-N-deacetyl-colchicine. Colcemid depolymerizes microtubules and blocks mitosis at metaphase.

Aplicação

Colcemid inhibits the formation of mitotic spindles. It is used to increase the percentage of metaphase cells for chromosome analysis.

Ações bioquímicas/fisiológicas

Often in karyotyping and cell cycle research it is desirable to increase the yield of mitotic cells in a particular phase of the cell cycle. This can be achieved in a variety of ways with the most popular being the use of a cell cycle synchronizing agent such as demecolcine. Demecolcine will arrest cells in metaphase with no remarkable effect on the biochemical events in mitotic cells or in synchronized G1 and S phase cells. White blood cells are often treated with demecolcine to arrest cells in metaphase.

forma física

Solution (10 μg/ml), filtered through 0.2 μm pore size membrane.

Outras notas

For life science research only. Not for use in diagnostic procedures.

Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

nwg

Ponto de fulgor (°F)

does not flash

Ponto de fulgor (°C)

does not flash

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Os clientes também visualizaram

Slide 1 of 6

1 of 6

Aphidicolin from Nigrospora sphaerica ≥98% (HPLC), powder

Sigma-Aldrich

A0781

Aphidicolin from Nigrospora sphaerica

Giemsa stain certified by the Biological Stain Commission

Sigma-Aldrich

G5637

Giemsa stain

Colchicina British Pharmacopoeia (BP) Reference Standard

BP1150

Colchicina

RO-3306 ≥98% (HPLC)

Sigma-Aldrich

SML0569

RO-3306

Aphidicolin, Ready Made Solution from Nigrospora sphaerica

Sigma-Aldrich

A4487

Aphidicolin, Ready Made Solution

L-Mimosine from Koa hoale seeds ≥98%

Sigma-Aldrich

M0253

L-Mimosine from Koa hoale seeds

Naiara Zoccal Saraiva et al.
Cloning and stem cells, 11(1), 141-152 (2009-02-20)
This study aimed to evaluate the effect of demecolcine, a microtubule-depolymerizing agent, on microtubule kinetics; to determine the best concentration of demecolcine as a chemically assisted enucleation agent in metaphase I (MI) and metaphase II (MII) bovine oocytes, and to
Vasiliki Tasiou et al.
PloS one, 10(8), e0134672-e0134672 (2015-08-15)
The human RB1 gene is imprinted due to integration of the PPP1R26P1 pseudogene into intron 2. PPP1R26P1 harbors the gametic differentially methylated region of the RB1 gene, CpG85, which is methylated in the female germ line. The paternally unmethylated CpG85
Candice L Wike et al.
eLife, 5, e11402-e11402 (2016-02-18)
Phosphorylation of histone H3 threonine 118 (H3 T118ph) weakens histone DNA-contacts, disrupting the nucleosome structure. We show that Aurora-A mediated H3 T118ph occurs at pericentromeres and chromosome arms during prophase and is lost upon chromosome alignment. Expression of H3 T118E
Roshan L Shrestha et al.
The Journal of cell biology, 220(4) (2021-02-24)
Chromosomal instability (CIN) is a hallmark of many cancers. Restricting the localization of centromeric histone H3 variant CENP-A to centromeres prevents CIN. CENP-A overexpression (OE) and mislocalization have been observed in cancers and correlate with poor prognosis; however, the molecular

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica