P3075

Phenylarsine oxide

≥97%, powder

• Sinônimo(s): Arzene, Oxophenylarsine, PAO
• Fórmula empírica (Notação de Hill): C₆H₅AsO
• Número CAS: 637-03-6
• Peso molecular: 168.02
• Beilstein: 2935227
• Número CE: 211-275-3
• Número MDL: MFCD00001990
• Código UNSPSC: 12352119
• ID de substância PubChem: 24898387
• NACRES: NA.77

Propriedades

• fonte biológica: synthetic (organic)
• Ensaio: ≥97%
• forma: powder
• cor: white to off-white
• pf: 145-148 °C
• solubilidade: DMSO: 50 mg/mL
• cadeia de caracteres SMILES: O=[As]c1ccccc1
• InChI: 1S/C6H5AsO/c8-7-6-4-2-1-3-5-6/h1-5H
• chave InChI: BQVCCPGCDUSGOE-UHFFFAOYSA-N

Descrição

Descrição geral

Phenylarsine oxide (PhAsO⁴) is a bifunctional SH group chemical. It is hydrophobic in nature.

Aplicação

Phenylarsine oxide has been used to infuse animals with a nigrostriatal transection, to determine whether peroxovanadium (pVa) would synergize with brain-derived neurotrophic factor (BDNF).

Ações bioquímicas/fisiológicas

Phenylarsine oxide (PAO) can reduce the motility and sustainability of Setaria cervi. It has the ability to stimulate cyclosporin A-sensitive transition in the presence of EGTA (ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid). It acts as a stimulator of mitochondrial ion fluxes.

Phenylarsine oxide inhibits internalization of cell surface receptors; inhibits tyrosine phosphatases, with no effect on tyrosine kinase. Metabolic poison.

Características e benefícios

This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informações de segurança

• Pictogramas: GHS06,GHS09
• Palavra indicadora: Danger
• Frases de perigo: H301 + H331,H410
• Declarações de precaução: P261 - P264 - P271 - P273 - P301 + P310 - P304 + P340 + P311
• Classificações de perigo: Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable