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P2371

Sigma-Aldrich

Pamidronate disodium salt hydrate

≥95% (NMR), solid

Sinônimo(s):

3-Amino-1-hydroxy-1-phosphonopropanephosphonic acid disodium salt hydrate

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About This Item

Fórmula empírica (Notação de Hill):
C3H9NO7P2Na2 · xH2O
Número CAS:
57248-88-1
Peso molecular:
279.03 (anhydrous basis)
Número CE:
260-647-1
Número MDL:
MFCD11045314
Código UNSPSC:
12352200
ID de substância PubChem:
24724574
NACRES:
NA.77

Ensaio

≥95% (NMR)

Formulário

solid

cor

white

pf

300 °C

solubilidade

H2O: 28 mg/mL

originador

Novartis

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

O.[Na+].[Na+].NCCC(O)(P(O)([O-])=O)P(O)([O-])=O

InChI

1S/C3H11NO7P2.2Na.H2O/c4-2-1-3(5,12(6,7)8)13(9,10)11;;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;;1H2/q;2*+1;/p-2

chave InChI

TVQNUQCYOOJTMK-UHFFFAOYSA-L

Categorias relacionadas

Ações bioquímicas/fisiológicas

Bone resorption inhibitor; inhibitor of farnesyl diphosphate synthase (IC50 = 200 nM).
Pamidronate disodium has the ability to block Wnt and β-catenin signaling, which modulates the osteogenic differentiation in bone marrow mesenchymal stem cells (BMMSCs). It can also reduce bilirubin-impaired apoptosis and helps to develop dentinogenic dysfunction of stem cells from human deciduous teeth.

Características e benefícios

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H302

Declarações de precaução

P264 - P270 - P301 + P312 - P501

Classificações de perigo

Acute Tox. 4 Oral

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
070M4707V
070M4707
058K47172
058K47171
058K4717

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Uncomplicated vaginal delivery in two consecutive pregnancies carried to term in a woman with osteogenesis imperfecta type I and bisphosphonate treatment before conception.
Chih-Ping Chen et al.
Taiwanese journal of obstetrics & gynecology, 51(2), 305-307 (2012-07-17)
Alexandre Loupy et al.
The Journal of clinical investigation, 122(9), 3355-3367 (2012-08-14)
Tight regulation of calcium levels is required for many critical biological functions. The Ca2+-sensing receptor (CaSR) expressed by parathyroid cells controls blood calcium concentration by regulating parathyroid hormone (PTH) secretion. However, CaSR is also expressed in other organs, such as
Coralie Leblicq et al.
Pediatric blood & cancer, 60(5), 741-747 (2012-09-25)
Osteonecrosis (ON) is a severe complication of acute lymphoblastic leukemia (ALL) treatments. Recent studies suggest that bisphosphonates might reduce pain and loss of motor function in patients with ON. We assessed the effects of pamidronate compared to standard care in
Pamidronate decreases bilirubin-impaired cell death and improves dentinogenic dysfunction of stem cells from human deciduous teeth
Yamaza H, et al.
Stem Cell Research & Therapy, 9(1), 303-303 (2018)
Pamidronate Disodium Leads to Bone Necrosis via Suppression of Wnt/beta-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells In Vitro
Xu Y, et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 75(10), 2135-2143 (2017)
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Discover Bioactive Small Molecules for Cyclic Nucleotides

Cyclic nucleotides, including cyclic AMP (cAMP), cyclic GMP (cGMP) and cyclic ADP-ribose, have been extensively studied as second messengers of intracellular events initiated by activation of GPCRs. cAMP modifies cell function in all eukaryotic cells, principally through the activation of cAMP-dependent protein kinase (PKA), but also through cAMP-gated ion channels and guanine nucleotide exchange factors directly activated by cAMP.

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