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P1645

Sigma-Aldrich

Palmitoyl-L-carnitine chloride

≥98% (TLC), powder

Sinônimo(s):

O-Palmitoyl-L-carnitine chloride

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About This Item

Fórmula linear:
C23H46NO4 · Cl
Número CAS:
18877-64-0
Peso molecular:
436.07
Beilstein:
4071005
Número CE:
242-642-6
Número MDL:
MFCD00070346
Código UNSPSC:
12352211
ID de substância PubChem:
24898229
NACRES:
NA.25

Ensaio

≥98% (TLC)

forma

powder

cor

white

solubilidade

H2O: 25 mg/mL (with heat or sonication)

tipo de lipídio

saturated FAs

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

[Cl-].CCCCCCCCCCCCCCCC(=O)O[C@H](CC(O)=O)C[N+](C)(C)C

InChI

1S/C23H45NO4.ClH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4;/h21H,5-20H2,1-4H3;1H/t21-;/m1./s1

chave InChI

GAMKNLFIHBMGQT-ZMBIFBSDSA-N

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Aplicação

Palmitoyl-L-carnitine chloride has been used as acylcarnitine in treating cardiomyocytes for the induction of reactive oxygen species (ROS).

Ações bioquímicas/fisiológicas

Long-chain acylcarnitine and well-known intermediate in mitochondrial fatty acid oxidation. Modifies myocardial levels of high-energy phosphates and free fatty acids in the heart. Increases erythroid colony formation in culture. Reduces surface negative charge of erythrocytes and myocytes. Reported to affect currents and inhibit endothelium-dependent relaxation induced by acetylcholine and substance P in a dose-dependent manner by suppressing the intracellular calcium signal transduction in endothelial cells. Inhibits the Na/K pump current but has no effect on the intracellular calcium current in guinea pig ventricular cells. However, like oubain, it reversibly depolarizes the resting membrane, decreases action potential duration, and increases the amplitude of myocyte contractions.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H315,H319,H335

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Supelco

08084

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Sigma-Aldrich

42602

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Sigma-Aldrich

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Sigma-Aldrich

07439

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Supelco

46940-U

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sn-Glycerol 3-phosphate bis(cyclohexylammonium) salt ≥93% (GC)

Sigma-Aldrich

G7886

sn-Glycerol 3-phosphate bis(cyclohexylammonium) salt

sn-Glycerol 3-phosphate lithium salt ≥95.0% (TLC)

Sigma-Aldrich

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sn-Glycerol 3-phosphate lithium salt

Sriram Devanathan et al.
Biology of sex differences, 7, 25-25 (2016-05-18)
Cardiovascular disease is the leading cause of death among diabetic patients. Importantly, recent data highlight the apparent sexual dimorphism in the pathogenesis of cardiovascular disease in diabetics with respect to both frequency- and age-related risk factors. The disposition to cardiovascular
M Matsumura et al.
American journal of nephrology, 18(5), 355-358 (1998-09-08)
The administration of L-carnitine to patients undergoing hemodialysis increases hematocrit and improves the response to recombinant human erythropoietin (rhEPO). This suggests a contribution by carnitine to erythrocyte membrane function or erythropoiesis. We investigated the effect of L-carnitine and palmitoyl-L-carnitine on
S R Stapleton et al.
British journal of pharmacology, 107(4), 1192-1197 (1992-12-01)
1. The effects of palmitoyl-DL-carnitine (0.01 to 1 mM) on whole cell voltage-activated calcium channel currents carried by calcium or barium and Ca(2+)-activated chloride currents were studied in cultured neurones from rat dorsal root ganglia. 2. Palmitoyl-DL-carnitine applied to the
Sexual dimorphism in myocardial acylcarnitine and triglyceride metabolism
Devanathan S, et al.
Biology of sex differences, 7(1), 25-25 (2016)
N Inoue et al.
Cardiovascular research, 28(1), 129-134 (1994-01-01)
Palmitoyl-L-carnitine, which accumulates in ischaemic myocardium, may influence the function of vascular endothelium in the ischaemic area. The aim of the study was therefore to examine the effect of palmitoyl-L-carnitine on endothelium dependent relaxations of rabbit thoracic aortas and its
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