N6655
Anti-Nerve Growth Factor 2.5S antibody produced in rabbit
fractionated antiserum, buffered aqueous solution
Sinônimo(s):
Anti-NGF-2.5S
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About This Item
Produtos recomendados
fonte biológica
rabbit
Nível de qualidade
conjugado
unconjugated
forma do anticorpo
fractionated antiserum
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
Formulário
buffered aqueous solution
reatividade de espécies
mouse, human
técnica(s)
Ouchterlony double diffusion: suitable
western blot: 1:2,000
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... NGF(4803)
mouse ... Ngf(18049)
Descrição geral
Nerve growth factor (NGF) belongs to the family of neurotrophic factors. It is located at 1p13.2 on the human chromosome. There are two molecular forms of NGF, 7S NGF and 2.5S NGF, that have identical neurotrophic effect on neurons.
Especificidade
May be used in monitoring for NGF (2.5S, β and 7S).
Imunogênio
NGF-2.5S from male mouse submaxillary glands.
Aplicação
Anti-Nerve Growth Factor 2.5S antibody may be used for immunoblotting and dot blot at a minimum antibody working dilution of 1:2000. Antibody dilution of 1:1000 was used for immunoblotting using extracts of nucleus raphe magus tissue of rats. The antibody was used for immunofluorescence of mouse astrocytes and for neutralization assays.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Western Blotting (1 paper)
Immunofluorescence (1 paper)
Western Blotting (1 paper)
Ações bioquímicas/fisiológicas
Mutations in this gene leads to hereditary sensory and autonomic neuropathies class five (HSAN-V).
forma física
Solution in phosphate buffered saline.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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7S nerve growth factor has different biological activity from 2.5 S nerve growth factor in vitro
Shao N, et al.
Brain Research, 609(1-2), 338-340 (1993)
N Shao et al.
Brain research, 609(1-2), 338-340 (1993-04-23)
It is considered that two molecular forms of nerve growth factor (NGF), that is 7S NGF and 2.5S NGF have the identical neurotrophic effect on neurons. We now report that 7S NGF has different biological activities from 2.5S NGF in
Liang-Wei Chen et al.
The Journal of comparative neurology, 497(6), 898-909 (2006-06-28)
To address the hypothesis that reactive astrocytes in the basal ganglia of an animal model of Parkinson's disease serve neurotrophic roles, we studied the expression pattern of neurotrophic factors in the basal ganglia of C57/Bl mice that had been treated
Joshua S Barker et al.
Journal of toxicology and environmental health. Part A, 78(6), 397-407 (2015-03-04)
Previous studies demonstrated that interleukin-1β (IL-1β) and nerve growth factor (NGF) increase synthesis of substance P (SP) in airway neurons both after ozone (O3) exposure and by direct application. It was postulated that NGF mediates O3-induced IL-1β effects on SP.
New protein fold revealed by a 2.3-
McDonald N Q, et al.
Nature, 354(6352), 411-411 (1991)
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